Drugs online research references
Psychopharmacology (Berl). 1982;78(2):180-4.
Classical and non-classical neuroleptics induce supersensitivity of nigral GABA-ergic mechanisms in the rat.
Coward DM.
The present study compared the ability of neuroleptic and non-neuroleptic agents to modify the sensitivity of nigral, GABA-sensitive, non-dopaminergic efferents in the rat after sub-chronic administration. Pre-treatment with haloperidol or clebopride, 1.0 mg/kg PO for 10 days, induced supersensitivity to the behavioural effects of unilateral intranigral muscimol, 5.0 ng, on withdrawal day 1. This effect was no longer significant in other rats tested on withdrawal day 7. In contrast, similar pre-treatment with sulpiride, 20 mg/kg PO, led to significantly enhanced responses to intra-nigral muscimol on both withdrawal days. Pre-treatment with clozapine, 20 mg/kg, or thioridazine, 12 mg/kg PO, did not lead to supersensitivity on withdrawal day 1, but did so on withdrawal day 7. Pre-treatment with amitriptyline, 20 mg/kg PO, or metoclopramide, 1.0 mg/kg PO, failed to result in supersensitivity on either withdrawal day. The data confirm previous biochemical and behavioural findings suggesting that repeated administration of neuroleptics can induce nigral GABA-ergic supersensitivity in the rat, but demonstrate that this action is not an exclusive property of classical, cataleptogenic agents.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6129672&dopt=Abstract
Naunyn Schmiedebergs Arch Pharmacol. 1975;288(2-3):215-31.
Arrhythmias and inhibition of noradrenaline uptake caused by tricyclic antidepressants and chlorpromazine on the isolated perfused rabbit heart.
Barth N, Manns M, Muscholl E.
1. Isolated rabbit hearts were perfused with a modified Tyrode solution containing noradrenaline in concentrations increasing stepwise from 5.9 nM to 5.9 muM at 5 min intervals. This dose regime was applied twice before and once 20 min after starting perfusion with one of 9 tricyclic drugs. Ventricular rate and right atrial and ventricular tensions were recorded using the transverse method. 2. Infusions of noradrenaline evoked ventricular arrhythmias in hearts perfused with amitriptyline 4.8 muM, chlorpromazine 5.0 muM, desipramine 5.0 muM, dibenzepine 34.7 muM, doxepin 4.7 muM, imipramine 4.7 muM, noxiptiline 9.1 muM and opipramole 9.2 muM. The incidence of arrhythmias increased with the concentration of noradrenaline applied and the dose of tricyclic drug administered. Whenever arrhythmias had started they continued as long as noradrenaline was infused. Noradrenaline failed to produce arrhythmias in hearts not exposed to drugs and after iprindole 4.7 muM or cocaine 2.9-18 muM. 3. Propranolol 0.1 muM inhibited the incidence of arrhythmias after doxepin 4.7 muM plus noradrenaline 5.9-190 nM. 4. Neuronal uptake of exogenous noradrenaline in the rabbit heart was inhibited by the tricyclic drugs in the following order of declining p potency: doxepin, noxiptiline, amitriptyline, desipramine, chlorpromazine, imipramine, dibenzepine, opipramole and iprindole. 5. Among tricyclic drugs the potency to inhibit amine uptake is related to the incidence of arrhythmias evoked by a submaximal concentration of noradrenaline. It appears, however, that these two parameters are not causally linked. 6. The isolated rabbit heart perfused with noradrenaline might be used as a model for testing the arrhythmogenic actions of tricyclic drugs and the treatment of such arrhythmias.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1161046&dopt=Abstract
Riv Sper Freniatr Med Leg Alien Ment. 1964 Sep 30;88:860-74.
[CONTRIBUTION TO THE STUDY OF THE ANTIDEPRESSIVE ACTION OF AMITRIPTYLINE]
[Article in Italian]
VERGA G.
PMID: 14231530 [PubMed - OLDMEDLINE for Pre1966]
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