Drugs online research references
Br J Psychiatry. 1965 Nov;111(480):1101-3.
A comparison of nortriptyline and amitriptyline in depression.
Rose JT, Leahy MR, Martin IC, Westhead TT.
PMID: 5841221
Psychopharmacologia. 1963 Apr 16;12:114-25.
AMITRIPTYLINE AND NORTRIPTYLINE AS ANTAGONISTS OF CENTRAL AND PERIPHERAL CHOLINERGIC ACTIVATION.
RATHBUN RC, SLATER IH.
PMID: 14050417 [PubMed - OLDMEDLINE for Pre1966]
Neuropsychobiology. 1986;16(2-3):97-102.
Amitriptyline and nortriptyline plasma levels, urinary 3-methoxy-4-hydroxyphenylglycol and clinical response in depressed women.
Corona GL, Cucchi ML, Frattini P, Santagostino G, Schinelli S, Comincioli V, Zerbi F, Fenoglio L, Savoldi F.
Thirty-eight depressed female inpatients, treated intramuscularly with 100 mg/day amitriptyline (AMT), were monitored to investigate the relationships between plasma levels of the drug and its metabolite nortriptyline (NT), the urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG), side effects and clinical response. Considering the whole group, the clinical improvement was better within an intermediate range of AMT plus NT plasma concentrations (100-200 ng/ml). A more favorable outcome was also observed at NT plasma levels below 55 ng/ml. No significantly different percent clinical response among the patient clinical subgroups was observed as well as no significant correlations between MHPG decrease and drug plasma levels.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3587582&dopt=Abstract
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