Drugs online research references
Toxicol Lett. 1987 Dec;39(2-3):199-204.
Cytogenetic effects of amitriptyline hydrochloride in somatic and germ cells of mice.
Chowdary PS, Rao MS.
Department of Genetics, Osmania University, Hyderabad, India.
Amitriptyline hydrochloride, an antidepressant drug, was tested in mice for mutagenic effects in the somatic cells by the micronucleus test and in the germ cells by the air drying technique of Evans et al. Mice were treated orally with the drug at a dose of 70, 140 and 210 mg/kg body weight. The results indicate that the drug is capable of inducing mutations both in the mitotic and meiotic cells of mice.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3686550&dopt=Abstract
Pharmakopsychiatr Neuropsychopharmakol. 1980 May;13(3):111-6.
On the relationship of nortriptyline: amitriptyline ratio to clinical improvement of amitriptyline treated depressive patients.
Jungkunz G, Kuss HJ.
The antidepressant effect of amitriptyline was studied in 28 endogenous depressive patients. They received 150 mg amitriptyline once nightly in a sustained release form for 4 weeks. Blood samples were drawn 12 hrs. after medication. Amitriptyline concentrations were between 35--300 ng/ml Nortriptyline concentrations were between 20--330 ng/ml. No correlations were found between plasma concentrations of amitriptyline, nortriptyline, or their sum, and the clinical outcome of treatment. Plasma levels of amitriptyline depended on neither the age nor the sex of the patients. A significant correlation was found between the ratio of nortriptyline to amitriptyline concentrations in serum (demethylation ratio) and clinical improvement. The demethylation ratio appeared to be relatively constant after a few days of treatment. The results suggest that monitoring the demethylation ratio of endogenous depressive patients treated with amitriptyline may predict therapeutic effects of the treatment. They also suggest that a balance between noradrenergic and serotonergic mechanisms is necessary to improve antidepressant treatment with amitriptyline.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7393997&dopt=Abstract
Scott Med J. 1964 Aug;117:341-4.
COMPARATIVE TRIAL OF NORTRIPTYLINE AND AMITRIPTYLINE.
FORREST AD, AFFLECK JW, GIBB IA, PRIEST RG.
PMID: 14179977 [PubMed - OLDMEDLINE for Pre1966]
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