Drugs online research references








Med J Aust. 1978 Mar 25;1(6):341-3.
Cardiological effects of nomifensine, a new antidepressant.

Burrows GD, Vohra J, Dumovic P, Scoggins BA, Davies B.

A cardiovascular study of a new antidepressant, nomifensine, revealed no significant cardiac effects in eight ambulant patients who received up to 200 mg of nomifensine per day for three weeks. In an electro-physiological study of cardiac conduction, nomifensine had significantly less effect on cardiac activity than amitriptyline and doxepin. Results of the clinical and the experimental studies suggest that nomifensine may be of value in treating the depressed patient with heart disease.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=661706&dopt=Abstract

Seishin Shinkeigaku Zasshi. 1987;89(1):22-42.
[The concentrations of amitriptyline, maprotiline and their demethylated metabolites, nortriptyline and desmethylmaprotiline, in rat plasma and brain]

[Article in Japanese]

Yufu N.

PMID: 3615663


Eur J Clin Pharmacol. 1989;37(6):595-8.
Amitriptyline: linear or nonlinear kinetics in every day practice?

Vandel S, Bertschy G, Vandel B, Allers G, Volmat R.

Laboratoire de Pharmacologie Clinique, CHU of Besancon, France.

The linearity of the (AMT) kinetics of amitriptyline has been tested in 135 depressed dosed twice daily by measuring plasma. Their (AMT) and nortriptyline (NT) levels under steady-state conditions. The AMT concentration/dose ratios at low and high dosages were not significantly different and there was a linear relationship between the dose ratios and the concentration ratios. No change in the metabolic ratio (AMT/NT) was observed between the two dosages. Although the results are consistent with linear AMT kinetics, there may have been nonlinear kinetics in some patients as the ratio between the concentration/dose ratios in them at low and high dosages was greater than one. Those patients were characterized by a low concentration/dose ratio at low dosage. No clinical adverse effect appeared in the study.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2612556&dopt=Abstract












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