Drugs online research references
J Immunoassay. 1980;1(1):57-75.
A radioreceptor assay for neuroleptic drugs in plasma.
Lader SR.
A simple and rapid method for measuring neuroleptic drugs in plasma by the estimation of dopamine receptor blocking activity is described. The assay has the advantages that it can be used without modification for all neuroleptic drugs and measures both parent compound as well as pharmacologically active metabolites. Intra-assay and inter-assay coefficients of variation are 20% and 30% respectively and sensitivity is adequate to measure drug activity in plasma from patients treated with oral neuroleptics but not for those receiving depot injections. Preliminary clinical investigations indicate that the ranges of dopamine receptor blocking activity in plasma vary for different drugs. Interference in the assay has been seen with some samples from patients receiving amitriptyline and nortriptyline, but not with other psychotropic drugs. The receptor assay is considered suitable for routine monitoring of neuroleptic drug therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6112242&dopt=Abstract
Biol Psychiatry. 1988 Jan 15;23(2):169-75.
Chronic treatment with amitriptyline produces supersensitivity to nicotine.
Dilsaver SC, Majchrzak MJ, Alessi NE.
Department of Psychiatry, University of Michigan, Ann Arbor 48109.
The authors used a thermoregulation paradigm to evaluate effects of amitriptyline (AMI) on the sensitivity of a nicotinic mechanism involved in the regulation of core temperature in rats. Treatment with this tricyclic was associated with a significant increase in the hypothermic response to nicotine. Supersensitivity persisted for a minimum of 7.5 days following the last dose of AMI, and a significant proportion of animals displayed increased sensitivity after 14.5 days of abstinence. Implications for the mechanism of action of AMI are highlighted.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3334885&dopt=Abstract
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