Drugs online research references
Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(1-2):297-302.
Chronic treatment with amitriptyline produces subsensitivity to the hypothermic effects of clonidine.
Dilsaver SC, Davidson R, Majchrzak M.
Department of Psychiatry, Ohio State University, Columbus.
1. Supersensitivity or up-regulation of presynaptic alpha 2-adrenoceptors may be involved in the pathogenesis of depression. 2. The authors used a thermoregulation paradigm to test the hypothesis that chronic treatment with a tricyclic antidepressant amitriptyline (AMI) produces subsensitivity to the hypothermic effects of the alpha 2 agonist clonidine. 3. Treatment with amitriptyline produced blunting of the hypothermic response to clonidine. 4. Subsensitivity persisted for at least 21 days--that point after the discontinuation of the tricyclic at which the animals were last challenged with clonidine. 5. These findings are consistent with previous reports that tricyclic antidepressants produce subsensitivity of alpha 2 adrenoceptors.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2748867&dopt=Abstract
J Nerv Ment Dis. 1986 Jul;174(7):414-7.
Hostility and recovery from melancholia.
Fava GA, Kellner R, Lisansky J, Park S, Perini GI, Zielezny M.
Twenty inpatients suffering from major depressive illness with melancholia were administered the hostility subscale of the Kellner Symptom Questionnaire and Paykel's Clinical Interview for Depression before and after treatment with amitriptyline. A matched control group of normal subjects had the same assessments at two points in time. Hostility decreased and friendliness increased in depressives after amitriptyline; upon recovery, there were no significant differences in hostility between depressed patients and control subjects, whereas such differences were striking during the illness. Patients who had reported losses before onset of illness rated themselves as more friendly than the other depressives; their hostility did not significantly decrease with recovery. The results suggest that hostility improves with the treatment of depression; life events appear to influence the degree of hostility in depressive illness as well as the response to treatment.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3723127&dopt=Abstract
Arch Gen Psychiatry. 1987 Feb;44(2):157-60.
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians.
Callies AL, Popkin MK.
The prescribing of antidepressants by nonpsychiatric physicians on adult medical-surgical inpatient services of a university hospital was examined through the review of medical records of patients who received amitriptyline hydrochloride, doxepin hydrochloride, or imipramine hydrochloride during a one-year period. Reasons for antidepressant use were treatment of depression (56%), pain (30%), or other conditions (14%). Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3813811&dopt=Abstract
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