Drugs online research references








Eur J Clin Pharmacol. 1977 Apr 20;11(4):311-5.
Cerebrospinal fluid amine metabolites after combined amitriptyline-triiodothyronine treatment of depressed women.

Banki CM.

Levels of 5-hydroxyindoleacetic acid and homovanillic acid were measured in cerebrospinal fluid from 33 depressed women with no clinical response to amitriptyline, before and after combination treatment with triiodothyronine. Although the latter showed significant clinical improvement, changes in CSF amine metabolites did not differ significantly from a control group of 16 therapy-resistant depressed women receiving higher doses of amitriptyline. Possible explanations for the mechanism of action of triiodothyronine are discussed.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=862653&dopt=Abstract

Psychopharmacologia. 1968;12(4):367-70.
The adrenal response to metyrapone in amitriptyline-treated subjects.

Fahy TJ, Gibbons JL.

PMID: 5652218


J Neural Transm. 1981;50(1):47-55.
Swim-induced grooming in mice is mediated by a dopaminergic substrate.

Chesher GB, Jackson DM.

Grooming induced in mice after a period of swimming was potently and dose-dependently blocked by neuroleptics. The order of potency of the neuroleptics was spiroperidol greater than haloperidol greater than cis-flupenthixol greater than pimozide greater than chlorpromazine greater than thioridazine. The trans isomer of flupenthixol was inactive at 40 microM/kg. The alpha-adrenergic receptor antagonists, phentolamine and phenoxybenzamine, and the catecholamine synthesis inhibitor, alpha-methyl-p-tyrosine were essentially without effect on the grooming behaviour. Amitriptyline inhibited grooming behaviour only in doses which severely affected the animals motor function. Fluoxetine was without effect. Cis-flupenthixol was less active in inhibiting grooming in animals chronically treated with haloperidol than in control animals, indicating the presence of supersensitive dopamine receptors. The data indicate that swim-induced grooming in mice is mediated via dopaminergic systems.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6110702&dopt=Abstract












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