Drugs online research references
Schweiz Med Wochenschr. 1965 Jan 30;95:173-6.
[TOXICITY STUDIES WITH AMITRIPTYLINE. THERAPEUTIC GUIDE LINES FROM EXPERIMENTAL STUDIES]
[Article in German]
SCHAERER K.
PMID: 14272853 [PubMed - OLDMEDLINE for Pre1966]
Psychopharmacology (Berl). 1984;84(4):574-6.
Single-dose single-point method in amitriptyline therapy.
Madakasira S, Khazanie PG, Sato TL.
Twenty-one depressed patients participated in a study that assessed the predictability of amitriptyline (AT) dosage based on plasma drug concentrations after a single dose. In 11 patients maintained on a fixed dose regimen, the 18-h single-dose level was confirmed to be predictive of steady-state levels. The dose for the next 10 patients was derived from their 18-h level aiming to attain steady-state levels of 200 ng/ml. The patients achieved a mean steady-state level of 213 ng/ml with 80% attaining therapeutic levels. All the patients improved within 2 weeks. These preliminary results suggest that dose prediction based on a single-dose TCA level is reliable and beneficial.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6441960&dopt=Abstract
Psychopharmacology (Berl). 1982;78(1):23-4.
A liquid chromatographic method for quantitating amitriptyline in brain tissue.
Preskorn SH, Glotzbach RK.
A previously reported method for measuring tricyclic antidepressants (TCA) in plasma was modified to measure TCA, specifically amitriptyline (AMI) and nortriptyline (NOR) in rat brain tissue. Brains obtained from drug-free and AMI-treated rats were extracted and assayed using a Waters high-performance liquid chromatograph. Drug-free brain tissue contained no substances which interfered with the assay of these TCAs. Drug recovery averaged 90 +/- 3.4% (mean +/- SEM). Seven intra-run assays of a spiked brain tissue sample yielded coefficients of variation of 2.7% for AMI and 1.8% for NOR. Seven inter-run assays of the same sample varied 4.2% for AMI and 3.5% for NOR. Five separate assays of a brain homogenate sample spiked with 50 ng/ml of drug yielded values of 50 +/- 2.1 SEM ng/ml for AMI and 54 +/- 1.1 SEM ng/ml for NOR. Standard curves were linear when constructed from samples in a concentration range of 250--3,000 ng/g wet weight tissue (r = 0.96, P less than 0.001).
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6815691&dopt=Abstract
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