Drugs online research references





J Chromatogr. 1980 Sep 19;197(2):246-50.
Liquid chromatography of amitriptyline and related tricyclic compounds.

Preskorn SH, Leonard K, Hignite C.

PMID: 7451597


Ann Clin Biochem. 1986 Sep;23 ( Pt 5):552-8.
An improved method for measurement of common tricyclic antidepressant drugs and their metabolites using normal phase HPLC.

Blakesley JD, Howse CG, Spencer-Peet J, Wood DC.

A sensitive HPLC method that allows the simultaneous determination of imipramine, amitriptyline and their desmethyl metabolites, using a 10 cm straight silica cartridge column with a mobile phase consisting of 0.004% perchloric acid in methanol is presented. Detection of the eluent is at 210 nm. The drugs are back-extracted from serum, giving both a good recovery and sensitivity of at least 5 micrograms/L. This method has proved to be extremely robust and reliable, with coefficients of variation around 3% being reported.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3767292&dopt=Abstract




J Clin Chem Clin Biochem. 1976 Sep;14(9):453-8.
Critical evaluation of measurement of platelet monoamine oxidase in man.

Honecker H, Christ W, Muller-Oerlinghausen B, Coper H.

Some biochemical characteristics such as substrate specificity, substrate affinity and inhibitor sensitivity of monoamine oxidase of human blood platelets were investigated. Tyramine, tryptamine and beta-phenylethylamine were used as substrates. The apparent Michaelis constants, maximal velocity rates and I50 for the inhibitor tranylcypromine were determined. The data were analyzed according to Lineweaver-Burk and Dixon. The influence of amitriptyline, a prototype of tricyclic antidepressants, on the selected variables (Km, V, I50), was studied. The parameters investigated showed remarkably low interindividual differences when healthy volunteers were tested. The inhibitor activity of amitriptyline towards platelet monoamine oxidase depends on the substrate used. Amitriptyline concentrations which showed a pronounced effect on the enzyme characteristics are significantly higher than plasma levels of the drug found under therapeutic conditions.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=965902&dopt=Abstract












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