Drugs online research references
Psychiatr Pol. 1977 Jul-Aug;11(4):397-402.
[Long-acting amitriptyline (lentizol) in the treatment of depression]
[Article in Polish]
Jakimow-Venulet B, Kalinowski A, Klosiewicz L, Parnowski T, Puzynski S, Waniek J.
PMID: 594226
J Cardiovasc Pharmacol. 1981 Nov-Dec;3(6):1221-8.
Effects of amitriptyline on left ventricular function in conscious dogs.
Lindenfeld J, Horwitz LD.
Amitriptyline (Am) is a frequently prescribed tricyclic antidepressant drug associated with an increased risk of sudden death that has been presumed to be arrhythmia related. Little has been known about the effects of Am on left ventricular function. We studied i.v. Am (0.5, 1.0, and 1.5 mg/kg) in 10 conscious, resting, chronically instrumented dogs. Heart rate (HR) increased up to 70%; this increase was only partially prevented by propranolol. Left ventricular end diastolic pressure (LVEDP) decreased without, but not with, propranolol. Mean arterial pressure (MAP) increased by 10-13% transiently. The maximum rate of rise of left ventricular pressure (dP/dtmax) decreased by 16-18% without propranolol and by 14-29% with propranolol, indicating a moderate decrease in myocardial contractility. Changes in stroke volume were similar to changes in dP/dt. Thus, i.v. Am, at levels similar to therapeutic blood levels, causes a moderate depression of myocardial contractility, which is accentuated by propranolol. Tricyclic antidepressants, therefore, could have adverse effects on cardiac performance in patients with underlying myocardial dysfunction.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6173521&dopt=Abstract
Arzneimittelforschung. 1980;30(2):335-7.
Plasma concentrations of amitriptyline during single nightly and thrice daily administration. Cross-over study.
De Maio D, Drago F, Nielsen P, Ascalone V, Cisternino M.
Plasma amitriptyline and nortriptyline concentrations were measured in ten depressed in-patients after administration of amitriptyline hydrochloride 75 mg in three divided doses or as a single nightly dose. Mean steady state plasma concentrations during the two dosage regimens were similar. Plasma level differences between dosage schedules at sampling times were small and not significant. It was concluded that the single nightly administration of amitriptyline is a helpful therapeutic schedule which can be used instead of the divided dose when the opportunity is given.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7378116&dopt=Abstract
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