Drugs online research references





Acta Pharmacol Toxicol (Copenh). 1967;25:Suppl 4:16-7.
The inhibiting effect of amitriptyline, bamipin and chlorprothixene on the content of adrenaline and noradrenaline in the adrenal vein of dogs and their adrenomedullary secretion caused by acetylcholine.

Manninen K, Pekkarinen A, Thomasson B.

PMID: 4384682


Arzneimittelforschung. 1978;28(10b):1916-20.
Comparative single-dose kinetics of amitriptyline and its N-oxide in a volunteer.

Breyer-Pfaff U, Ewert M, Wiatr R.

Plasma drug levels and urinary metabolites were measured in a volunteer for 28 h after ingestion of amitriptyline hydrochloride or amitriptyline N-oxide (amitriptylinoxide) equivalent to 100 mg of amitriptyline base. The N-oxide initially produced high plasma levels and 15% of the dose was excreted unchanged within 14 h. From comparison of the metabolite excretions, it can be concluded that about 70% of the dose was reduced at the N-oxide group, while comparison of the areas under the plasma group, while comparison of the areas under the plasma level-time curves for amitriptyline pointed to a 55% reduction to the amine. Less drowsiness was experienced after ingesting the N-oxide, and there was no depressive mood.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=582519&dopt=Abstract




Neurosci Lett. 1986 Sep 25;70(1):28-33.
Effect of amitriptyline on laminar differentiation of neonatal rat olfactory bulb.

Chuah MI, Hui BS.

Amitriptyline (AT) was injected i.p. (0.01 g/kg) into newborn rats for 12 days. Stereometric measurements of coronal sections of the olfactory bulbs showed that the area of the external plexiform layer (EPL) in the AT-treated group was significantly smaller than that of control rats. Rats treated with AT also showed a significantly lower increase in body weight compared with the saline-injected control group.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3774216&dopt=Abstract












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