Drugs online research references
Dan Med Bull. 1966 Nov;13(8):201-3.
Poisoning by amitriptyline, imipramine and nortriptyline.
Rasmussen J.
PMID: 5978770
Acta Microbiol Acad Sci Hung. 1980;27(1):55-61.
Lack of correlation between intercalation and plasmid curing ability of some tricyclic compounds.
Barabas K, Molnar J.
Some tricyclic psychotropic drugs are known to have plasmid curing activity. The interaction with DNA of three plasmid curing (chlorpromazine, amitriptyline, imipramine) and four ineffective (methylene blue, 7,8-dioxo-chlorpromazine, thiazinamium, chlorpromazine sulphoxide) compounds was studied by fluorescence polarization and circular dichroism methods. Among the seven compounds three, namely chlorpromazine, 7,8-O2-chlorpromazine, and methylene blue showed an intercalation effect. Other phenothiazines such as chlorpromazine sulphoxide and thiazinamium were not able to intercalate into Escherichia coli DNA, neither did the plasmid curing drugs amitryptyline and imipramine. It is concluded that the plasmid curing ability is not necessarily related to the intercalation ability.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6106347&dopt=Abstract
Can J Physiol Pharmacol. 1981 Sep;59(9):994-1001.
Stimulus-secretion coupling in exocrine pancreas; possible role of calmodulin.
Heisler S, Chauvelot L, Desjardins D, Noel C, Lambert H, Desy-Audet L.
Many calcium-mediated effects in mammalian cells may be activated by calcium-calmodulin stimulated enzymes. These effects are inhibited by various antidepressant drugs which bind to and inactivate calmodulin. In the current study, calmodulin was identified by affinity chromatography and gel electrophoresis in the cytoplasm of dispersed rat pancreatic acinar cells. Its role in enzyme secretion was assessed by evaluating the effects of various antidepressants drugs on the enzyme secretory process. Chlorpromazine, trifluoperazine, thioridazine, chlorprothixene and amitriptyline inhibited amylase secretion stimulated by carbachol, A-23187, and cholecystokinin-pancreozymin but not that elicited by dibutyryl cyclic AMP secretin or vasoactive intestinal peptide (VIP). Haloperidol, sulpiride, phenobarbital, and ethanol were without effect on secretagogue-stimulated enzyme release. Only those agents which blocked secretion also inhibited 45Ca release stimulated by carbachol from isotope preloaded cells. The data suggest that calmodulin may have a functional role in pancreatic enzyme secretion.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6170412&dopt=Abstract
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