Drugs online research references
Sleep. 1978 Winter;1(2):149-59.
Amitriptyline and EEG sleep in depressed patients: I. Drug effect.
Kupfer DJ, Spiker DG, Coble P, McPartland RJ.
The paucity of studies on the tricyclic antidepressants led us to conduct an investigation on 30 drug-free patients treated with amitryptyline in a double-blind protocol over a 4-week period. Consistent with previous reports, there was an immediate REM suppression on 50 mg, which was more pronounced at the 100-mg level. However, no significant incremental changes were noticed on 150 or 200 mg with regard to REM sleep suppression. Drug administration was associated with changes in other sleep variables such as stage 1 percent, stage 2 percent, and various measures of sleep continuity. The incomplete tolerance of the drug on certain REM sleep variables enhances our understanding of amitryptyline effects on the EEG sleep of depressed patients.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=227029&dopt=Abstract
Am J Psychiatry. 1960 Nov;117:455-6.
On the parenteral use of amitriptyline (ElavilMerck): a preliminary report.
FREED H.
PMID: 13701593 [PubMed - OLDMEDLINE for Pre1966]
Lancet. 1988 Jul 9;2(8602):90-2.
Blood disorders and suicide in patients taking mianserin or amitriptyline.
Inman WH.
Drug Safety Research Unit, North Croft House, Botley, Southampton.
26,781 patients who had been prescribed mianserin and 42,082 prescribed amitriptyline were followed up by means of a questionnaire addressed to their general practitioners. No patient had aplastic anaemia, agranulocytosis, or leucopenia severe enough to endanger life, and in only 2 patients in each group was a causal association likely. If either drug dose cause leucopenia, the incidence is likely to be in the range of 1 in 10,000 to 1 in 100,000 patients. Among patients who were reported to have attempted suicide, 56 of 246 survivors of amitriptyline overdoses required intensive care, compared with none of 92 patients who overdosed with mianserin. 4 patients who overdosed with amitriptyline alone died, compared with none of the patients who overdosed with mianserin alone. Both drugs are associated with a low risk of blood disorders, but mianserin is appreciably safer than amitriptyline because of its low toxicity in overdosage.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2898709&dopt=Abstract
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