Drugs online research references





Analyst. 1985 Sep;110(9):1091-4.
Construction of ion-selective electrodes for chlorpromazine, amitriptyline, propantheline and meperidine: analytical study and application to pharmaceutical analysis.

Mitsana-Papazoglou A, Christopoulos TK, Diamandis EP, Hadjiioannou TP.

PMID: 4061861 J Physiol (Paris). 1963 Sep-Oct;55:581-609.
[ATTEMPTED LOCALIZATION AND INTERPRETATION OF THE ACTION OF AMITRIPTYLINE AT THE LEVEL OF THE NERVOUS SYSTEM]

[Article in French]

MERCIER J, ETZENSPERGER P, DESSAIGNE S.

PMID: 14099064 [PubMed - OLDMEDLINE for Pre1966]


Pharmacol Biochem Behav. 1977 Aug;7(2):159-65.
Mechanisms of amitriptyline induced hypothermia in the rat.

Lee HK, Chai CY, Wayner MJ, Chung PM, Cheng JT.

Effects of amitriptyline on rectal temperature of male rats were studied at the ambient temperature of 25 degrees C. Drugs were administered intraperitoneally. Amitryptyline elicited a dose related hypothermia. The hypothermia was attenuated by phenoxybenzamine 10 mg/kg, haloperidol 2 mg/kg, diphenhydramine 5 mg/kg, atropine 20 mg/kg, and cyproheptadine 5 mg/kg. Propranolol, at a dose of 5 mg/kg, had no effect on the hypothermia. Theophylline 50 mg/kg and dibutyryl cyclic AMP 20 mg/kg inhibited the hypothermia produced by anitriptyline. Pretreatment with parachloroamphetamine (PCA), 2 or 5 mg/kg daily for 3 days, strongly antagonized the hypothermia. In addition, pretreatment with parachlorophenylalanine (PCPA), 100 mg/kg daily for three days, reduced the brain 5-hydroxytryptamine (5-HT) concentration to 20% of the control level and completely blocked the hypothermia response. When brain 5-HT concentration recovered to 50% of the control level in PCPA treated rats following the administration of 10 mg/kg 5-hydroxytryptophan (5-HTP) the hypothermia induced by amitriptyline was restored. However, the administration of 5-HT, 5 mg/kg, to PCPA treated rats did not increase brain 5-HT concentration or restore the amitriptyline induced hypothermia (AIH). Results suggest that amitriptyline interacts with several transmitter substances to produce hypothermia. Since the ability of amitriptyline to produce hypothermia was correlated with brain 5-HT content, 5-HT might play an important role in the mediation of AIH.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=199909&dopt=Abstract












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