Drugs online research references








Br J Anaesth. 1983 May;55(5):457-9.
Antidepressants do not increase the lethality of ketamine in mice.

Bruce DL, Capan L.

Swiss-Webster mice were allocated to 35 groups of 20 each, including controls, to evaluate the effect of pretreatment with antidepressant drugs on the LD50 of ketamine i.p. Deaths occurred only in groups given ketamine 400 or 600 mg kg-1. Within these groups, there were no consistent differences among untreated mice and those given one of three daily doses of either a tricyclic (amitriptyline) or monoamine oxidase inhibitor (tranylcypromine) antidepressant in their drinking water for 19 days before the ketamine injections. The ketamine LD50 values for the three major pretreatment groups were: controls 400 mg kg-1; amitriptyline 478 mg kg-1; tranylcypromine 483 mg kg-1. Although non-fatal additive toxicity is not ruled out by these findings, mortality from ketamine was not increased by pretreatment with either type of antidepressant.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6849728&dopt=Abstract




Anesth Analg. 1978 Jan-Feb;57(1):77-83.
Amitriptyline therapy increases electrocardiographic changes during reversal of neuromuscular blockade.

Glisson SN, Fajardo L, El-Etr AA.

Induction of anesthesia is associated with an increased incidence of cardiac arrhythmias in patients maintained on amitriptyline medication. This study presents additional evidence showing that, in experimental animals (cats), amitriptyline treatment also produces significant ST-T wave and conduction abnormalities during neostigmine reversal of neuromuscular blockade.

online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=564646&dopt=Abstract

Eur J Pharmacol. 1974 Sep;28(1):178-88.
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline and doxepin in conscious rabbits.

Elonen E, Mattila MJ, Saarnivaara L.

PMID: 4430320










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