Drugs online research references
Ir J Med Sci. 1975 Jul;144(7):249-54.
Effects of reserpine, chlorpromazine, imipramine and amitriptyline on urinary excretion of adenosine 3' 5' cyclic monophosphate in rats.
Keatinge AM, Sinanan K, Love WC.
PMID: 171237
J Pharm Pharmacol. 1985 Sep;37(9):610-3.
In-vitro enhancement of cholesterol dissolution by commonly used drugs.
King RO, Bell GD, Short AH, Heathcote BV, Hawkey CJ.
A rotating disc apparatus was used to study the dissolution of cholesterol in sodium cholate solutions and ox bile. Drugs with structures that render them capable of lowering interfacial resistance were tested and shown to increase cholesterol dissolution rates in both systems. In sodium cholate solutions, loperamide (3 X 10(-4)M) increased the rate of dissolution by over six times, and a similar effect was observed with amitriptyline (3 X 10(-3)M), diphenhydramine (3 X 10(-3)M), dicyclomine (3 X 10(-3)M) and propantheline (3 X 10(-3)M). These drugs are as effective as benzalkonium chloride at these concentrations. Amitriptyline, propantheline, dicyclomine and diphenhydramine also increased cholesterol dissolution rates into ox bile. If these drugs are excreted into human bile in sufficient quantities and in an active form they may be able to enhance the speed of cholesterol gallstone dissolution therapy.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2867179&dopt=Abstract
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