Drugs online research references
Psychopharmacology (Berl). 1977 Aug 31;54(1):57-60.
Noradrenaline, depressive illness, and the action of amitriptyline.
Ghose K, Coppen A.
The tyramine-dose/pressor response test was carried out on a series of patients suffering from primary depressive illness before and during treatment with amitriptyline. The severity of their depression was assessed during the study of the Hamilton Rating Scale (HRS). The decreased tyramine sensitivity induced by the drug, which is related to the inhibition of NA reuptake, correlated significantly with the plasma concentration of nortriptyline. However, contrary to the expectation of the noradrenaline hypothesis of depression, the decreased tyramine sensitivity, i.e., the degree of NA-reuptake blockade, did not show any correlation with clinical improvement following 6 weeks' treatment with amitriptyline.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=410061&dopt=Abstract
Br Med J. 1975 Mar 1;1(5956):516-7.
Letter: Amitriptyline and imipramine poisoning in children.
Carpenter DC, Beaubien AR, Mathieu LF, Hrdina PD.
PMID: 1125614
Psychopharmacology (Berl). 1985;87(2):212-5.
Cardiovascular effects of amitriptyline in the treatment of elderly depressed patients.
Christensen P, Thomsen HY, Pedersen OL, Thayssen P, Oxhoj H, Kragh-Sorensen P, Gram LF.
Thirteen elderly depressed patients (age 60-82 years) were treated for 5 weeks with a fixed dose of amitriptyline 100 mg (sustained release preparation). In all patients the sum of concentrations of amitriptyline and nortriptyline exceeded 130 micrograms/l, which is the recommended plasma level. Cardiovascular side effects were recorded by monitoring heart rate, blood pressure, standard ECG and systolic time intervals. During treatment, a transient increase in the supine heart rate was observed without significant changes in the supine blood pressure. The orthostatic drop in blood pressure was markedly increased during treatment without a compensatory increase in heart rate, and these changes remained significant during the whole investigational period. PQ and QRS were significantly increased during treatment, and significant changes in the systolic time intervals were found indicating impairment of myocardial conduction and contractility. In three patients medication was discontinued due to cardiovascular side effects.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3931149&dopt=Abstract
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