Drugs online research references
Gan To Kagaku Ryoho. 1991 Nov;18(14):2463-6.
[Prophylactic effect of allopurinol mouthwash against stomatitis induced by the chemotherapy (PMUE regimen) for gastrointestinal malignancies]
[Article in Japanese]
Fujimura T, Shima Y, Sawasaki K, Haryo S, Fujita H, Anada E, Shiota S.
Dept. of Surgery, Takaoka City Hospital, Japan.
For prevention of the chemotherapy-induced stomatitis we administered allopurinol mouthwash to 15 out of 38 patients who underwent PMUE regimen. The severity of stomatitis was graded on five scales according to the criteria of Japan Society For Cancer Therapy. The incidence of stomatitis was defined as patients number with stomatitis above Grade 2/all patients number. Six of 23 patients which were not given allopurinol mouthwash (control group) developed stomatitis of Grade 1 (three patients), Grade 3 (two), or Grade 4 (one). Only one patient given allopurinol mouthwash (AMW group), however, suffered from Grade 1 stomatitis. The incidence of stomatitis was 13.0% for a control group and 0% for an AMW group. The average graded toxicity was 0.07 for the AMW group significantly lower than 0.57 for the control group. There was no significant difference between the two groups in other clinical adverse effects or abnormal laboratory data. These results suggested that allopurinol mouthwash regimen was well tolerated and effective for prevention of the chemotherapy induced stomatitis.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1952966&dopt=Abstract
Klin Wochenschr. 1991 Dec 15;69(21-23):1095-8.
Oxygen radicals in liver ischemia and reperfusion--experimental data.
Kunz R, Schoenberg MH, Buchler M, Jost K, Beger HG.
Chirurgie I, Universitat Ulm.
The generation of free oxygen radicals is presumed as a substantial pathogenetic principle in reperfusion injury. Although demonstrated in gut, muscle and kidneys its role in liver reperfusion injury is still under investigation. In an experimental rat model of warm liver ischemia of 60 min and 8 h reperfusion electron resonance spectroscopy assessed the increased generation of free radicals in early reperfusion period, leading to a decrease of polyunsaturated free fatty acids in liver tissue within 15 min of reperfusion. Histologically, single cell death, local and patchy necrosis of hepatic lobuli could be observed after 8 h reperfusion (n = 6). These histologic signs of liver injury could be attenuated by administration of superoxide-dismutase in combination with catalase but not by allopurinol. Best results could be obtained by deferoxamine. This indicates that increased generation of free oxygen radicals in reperfusion is not caused by the known conversion of xanthine-dehydrogenase to -oxidase but is mediated by an increased generation of hydroxyl-radicals, which can be scavenged by deferoxamine.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1665885&dopt=Abstract
Jpn Circ J. 1991 May;55(5):490-9.
A useful canine model of ischemic myocardium with coronary retrograde flow diversion, and its application for the study of allopurinol on myocardial infarct size.
Motoe M, Yoshida S.
Second Department of Internal Medicine, Sapporo Medical College, Japan.
This study was undertaken to evaluate the usefulness of a canine ischemic heart model achieved by coronary retrograde flow (RF) diversion, and to examine the effect of allopurinol on the myocardial infarction. The left anterior descending coronary artery (LAD) was occluded for 90 min followed by 4h reperfusion. Group 1 (n = 9) was a simple LAD occlusion group. In group 2 (n = 8), retrograde flowing blood from the distal of the occluded LAD was simultaneously diverted during LAD occlusion. In group 3 (n = 8), allopurinol was administered 60 min before ischemia with RF diversion followed by its continuous infusion. Infarcted myocardium was determined by triphenyl tetrazolium chloride staining and myocardium at risk by the dye double perfusion technique. RF diversion significantly reduced not only regional myocardial blood flow (RBF) (0.21 +/- 0.05 ml/min/g in group 1 vs 0.05 +/- 0.01 ml/min/g in group 2; p less than 0.05) but also its variance (p less than 0.01). Furthermore, the infarct size (infarct/risk ratio) in the allopurinol treated group was significantly reduced without any significant difference in rate pressure product, risk size or RBF (89.4 +/- 4.0% in group 2 vs 48.9 +/- 4.5% in group 3; p less than 0.01). We conclude that the canine RF diversion model is useful for myocardial infarct study because of the minimizing of the difference of collateral flow, and that canine myocardial xanthine oxidase may produce free radicals which take part in myocardial injury after reperfusion.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2062000&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics