Drugs online research references
Wien Klin Wochenschr. 1975 Dec 12;87(23):788-92.
[Clinical significance of hyperuricaemia in medically-hospitalized women over 50 years of age (author's transl)]
[Article in German]
Klotz HG, Hahn S, Koller G.
Hyperuricaemia was detected in 150 female patients over 50 years of age in a medical ward and was studied in detail. Serum uric acid levels over 6.2 mg/100 ml were found in 29.1% of the females of this age group, the incidence of idiopathic hyperuricaemia being 6.4%. The most common causes of urate elevation were the ingestion of diurectics (32%), pulmonary diseases (20%) and idiopathic hyperuricaemia (24%). These findings suggest that treatment with saliuretics, especially in the case of hypertensive cardiovascular disease, requires the control of serum uric acid levels. When serum uric acid levels are found to be elevated, treatment with allopurinol is essential.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1216845&dopt=Abstract
Burns. 1997 Feb;23(1):43-9.
Effects of allopurinol, ibuprofen and cyclosporin A on local microcirculatory disturbance due to burn injuries.
Cetinkale O, Demir M, Sayman HB, Ayan F, Onsel C.
Department of Emergency, Istanbul University, Cerrahpasa Medical Faculty, Turkey.
This experiment was designed to study the reactions in the surrounding area of burn injury that may lead to further necrosis in 24 h. To prevent extension of burn size into the tissue adjacent to burn injury, it was attempted to reduce progressive microvascular damage by different drugs (ibuprofen, allopurinol or cyclosporin A (CyA)) in a rat model. The burn model consisted of a row of four 10 x 20 mm burn areas separated by three unburned 5 x 20 mm skin bridges (interspaces). To evaluate microcirculation and perfusion of panniculus carnosus muscle which is beneath the burned area of skin, the radioactive agent, technetium-99m methoxyisobutylisonitrile (99Tc01-MIBI) was used 24 h after the burn. Capillary permeability of injured tissue was assessed by the wet and dry weight technique. In all study groups, interspaces showed higher uptakes of 99Tc01-MIBI between 40 and 95 per cent, in comparison with burn sites in the first 24 h following burn. Among the treated rats better results were obtained by allopurinol and CyA treatment that commenced before burn than ibuprofen. Wet and dry ratios were found to be significantly lower in interspaces in rats pretreated with allopurinol and CyA. Results of this experiment showed that neutrophils and free radical-mediated injury may be involved in the pathogenesis of local response to thermal injury, and allopurinol and CyA have some effects to prevent progressive ischemia, capillary compromise and oedema.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9115609&dopt=Abstract
Stroke. 1994 Jul;25(7):1463-7; discussion 1468.
Increased expression of ICAM-1 during reoxygenation in brain endothelial cells.
Hess DC, Zhao W, Carroll J, McEachin M, Buchanan K.
Department of Neurology, Veterans Affairs Medical Center, Augusta, Ga.
BACKGROUND AND PURPOSE: Thrombolysis is a promising therapy for acute ischemic stroke. However, there is evidence that neutrophils may physically plug cerebral microvessels on reperfusion, preventing the full benefit of thrombolysis. We undertook this study to determine whether there was increased endothelial expression of the intercellular adhesion molecule-1 (ICAM-1) gene during hypoxia-reoxygenation. METHODS: We isolated and cultured human brain microvascular endothelial cells and subjected them to hypoxia (PO2 < 10 mm Hg) in an anaerobic chamber followed by variable periods of reoxygenation. RESULTS: Twenty-hour periods of hypoxia did not lead to endothelial cytotoxicity as measured by a chromium-release assay. By Northern blot analysis, ICAM-1 mRNA transcripts were dramatically increased at 4 hours of reoxygenation but fell toward baseline (normoxia) by 12 and 24 hours. Hypoxia alone did not lead to an increase in mRNA levels. Western blot analysis showed an increased expression of ICAM-1 at 4, 12, and 24 hours of reoxygenation. The 4-hour increase in mRNA levels was not attenuated by pretreatment with 100 mumol/L allopurinol but was reduced by 30% with the addition of 20 mmol/L N-acetyl-L-cysteine at the time of reoxygenation and completely prevented by pretreatment with N-acetyl-L-cysteine. CONCLUSIONS: Hypoxia-reoxygenation leads to an increase in ICAM mRNA levels that peaks at 4 hours in human brain microvascular endothelial cells. Pretreatment with N-acetyl-L-cysteine can completely block the increase in ICAM-1 mRNA levels.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7912865&dopt=Abstract
online pharmacies ||
Hair Million herbal formula for hair loss and hair growth ||
Amoxicillin ||
Tramadol ||
Paxil ||
Rx Drugs USA, Prescription Drugs Online Pharmacy ||
Zithromax ||
online pharmacy ||
Antibiotics and prescription medications online literature ||
Antibiotics