Drugs online research references
ORL J Otorhinolaryngol Relat Spec. 1999 Jul-Aug;61(4):212-4.
Prognostic factors in patients with idiopathic facial paralysis (Bell's palsy): A prospective study.
Prim MP, De Diego JI, Sanz O.
Department of Otorhinolaryngology, La Paz Hospital, Autonomous University of Madrid, Spain.
A prospective study was designed in order to objectively quantify the most important prognostic factors of idiopathic facial paralysis (Bell's palsy). Stepwise logistic regression was applied to data obtained from 178 patients evaluated between April 1994 and September 1995 at La Paz Hospital. Due to statistical requirements, the final number of cases analyzed was 124. In all cases, 28 variables were recorded. The 3 variables selected by the multivariate analysis were: age, maximal stimulation test and treatment employed (prednisone or acyclovir). With these data, a linear discriminant function was obtained with an overall accuracy of 70.8%. The correct prediction rate for complete facial recovery was 82.1% and for absence of complete facial recovery 50.0%.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10450056&dopt=Abstract
J Antimicrob Chemother. 1997 Jun;39(6):821-4.
Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir.
Hayashi K, Hayashi T, Otsuka H, Takeda Y.
Department of Virology, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
A naturally occurring flavone, 5,6,7-trimethoxyflavone (TMF), isolated from the plant Callicarpa japonica, was subjected to antiviral assays. The compound exhibited relatively high inhibitory effects on herpes simplex virus type 1 (HSV-1), human cytomegalovirus and poliovirus. The anti-HSV-1 action was not due to the inhibition of virus adsorption, entry and viral protein synthesis, but might involve, at least in part, a virucidal activity, which results in a suppression of viral binding to host cells at an early replication stage. TMF and acylovir were synergic in their anti-HSV activities at levels below the 50% inhibitory concentrations for antiviral activity.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9222055&dopt=Abstract
J Infect Dis. 1994 Jun;169(6):1338-41.
Recurrence and resistance patterns of herpes simplex virus following cessation of > or = 6 years of chronic suppression with acyclovir. Acyclovir Study Group.
Fife KH, Crumpacker CS, Mertz GJ, Hill EL, Boone GS.
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5124.
Questions have arisen regarding the clinical outcome and the possible selection of resistant virus when patients with genital herpes discontinue prolonged chronic acyclovir; 239 immunocompetent patients with a history of frequently recurring genital herpes who stopped successful suppressive therapy after 6 years were studied. Of the patients, 85.8% had at least one recurrence and 75% had at least two recurrences in the subsequent year (median time to first and second recurrence, 68 and 180 days, respectively). Herpes simplex virus isolates recovered from these patients had a median acyclovir sensitivity of 0.79 micrograms/mL and 4 (3.5%) were resistant (> or = 3 micrograms/mL). These values are comparable to those of pretherapy isolates and to reported values of isolates from acyclovir-naive patients. Also, paired pre- and posttherapy isolates from 13 patients showed no trend toward development of resistance. Thus, even after 6 years of acyclovir suppression, most patients continue to have recurrences, but the selection of resistant virus has not been observed.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8195614&dopt=Abstract
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