Drugs online research references
Ann Ophthalmol. 1993 Jul;25(7):271-6.
Altering clinical features of recurrent herpes simplex virus-induced keratitis.
Uchio E, Hatano H, Ohno S.
Department of Ophthalmology, Yokohama City, University School of Medicine, Japan.
We studied the alteration in the clinical features of herpes simplex virus-induced keratitis (HSK) after the introduction of acyclovir (ACV) (in 1986). Over a nine-year period, this study investigated 101 patients (52 men and 49 women) whose conditions were diagnosed clinically as HSK. In addition, HSK recurred in 48 (47.5%) of the 101 patients. The distribution of clinical types of primary HSK before 1985 did not differ from that after 1986. Recurrent HSK was significantly more frequent in patients aged 26 to 40 years (75.0%). Although the five-year recurrence rates in primary HSK treated with ACV were significantly lower than those in patients treated with idoxuridine, the recurrence frequency before 1985 was equal to that after 1986. The discordance of the decreased recurrence rate in ACV-treated patients and the high recurrence frequency in patients with recurrent disease after the introduction of ACV were considered to be the result of the incomplete inhibitory effect of this drug.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8395784&dopt=Abstract
Mol Biol (Mosk). 1995 May-Jun;29(3):689-700.
[New nucleotide inhibitors of human DNA polymerase alpha]
[Article in Russian]
Semizarov DG, Ias'ko MV, Kukhanova MK, Kraevskii AA.
2'-Deoxythymidine 5'-triphosphate and 2'-deoxyadenosine 5'-triphosphate analogs containing a methylene group between the alpha phosphorus and 5' oxygen were synthesized. The substrate properties of these compounds toward some mammalian DNA polymerases and retroviral reverse transcriptases were evaluated using a system containing phage M13mp10 DNA, a synthetic oligonucleotide, and the enzyme. The compounds containing a hydroxyl at the 3' position were incorporated into the DNA chain by DNA polymerase alpha and terminal deoxynucleotidyl transferase, but were not recognized by retroviral reverse transcriptases and mammalian DNA polymerases epsilon and beta. The selectivity of the compounds synthesized was capitalized on during simultaneous isolation of DNA polymerases alpha and epsilon from human placenta. A methylene group was also introduced into the acyclovir molecule. It was shown that this modification inactivates furanose-related nucleotide analogs, but has a minor effect on the substrate properties of acyclic nucleotide analogs.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8552070&dopt=Abstract
J Neurol Neurosurg Psychiatry. 1997 Aug;63(2):222-7.
Cognitive recovery instead of decline after acute encephalitis: a prospective follow up study.
Hokkanen L, Launes J.
Institute of Neuroscience, Department of Neurology, University of Helsinki, Finland.
OBJECTIVE: Follow up of cognitive sequelae of acute encephalitis and estimation of the frequency of persisting dementia. METHODS: Out of a series of 45 consecutive patients with acute encephalitis prospectively studied in 1990-95, 40 were screened for difficulty in everyday life using the Blessed dementia scale (BDS) 3.7 (1.4), mean (SD), years after onset. Eight patients had had herpes simplex encephalitis (HSVE), 16 some other identified aetiology, and in 21 the aetiology was unknown. All, except two patients with a nonherpetic encephalitis, were treated with acyclovir. All patients with disability in BDS (12/40), were invited to a neuropsychological reassessment, and the results of this assessment were compared with those of a similar assessment done after the acute stage. At follow up one patient could not complete the tests due to intractable epilepsy. RESULTS: In six of 11 cases the symptoms causing disability were mainly psychiatric. Five patients (two with HSVE) had a pronounced memory impairment together with other cognitive deficits, indicating dementia (frequency of 12.8%). In eight of the 11 testable cases cognitive performance had improved over the years, in two cases a decline was found and one patient with severe deficits showed no change. Intractable epilepsy was found in four of 12 cases. CONCLUSION: Cognitive decline had taken place already at the acute stage, and further deterioration was uncommon. Considerable improvement occurred in most patients during follow up. Also in patients with HSVE treated with acyclovir the cognitive recovery was substantial and of a magnitude not expected based on previous literature. Intractable epilepsy contributed to the cognitive deterioration in some cases. Affective disorders also had a surprisingly important role for the long term outcome.
online pharmacy ref source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9285462&dopt=Abstract
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