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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs || hair research abs || hair related research references

ORL J Otorhinolaryngol Relat Spec. 2003 Mar-Apr;65(2):97-102.
Vestibular morphology in the mutant mix-mouse.

Sato H, Bagger-Sjoback D, Hultcrantz M.

Institute for Hearing and Communication Research, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden. haruenotmail.com

Mix-mice, a new strain of mice with inner ear dysfunction, and their littermates were used in the present study in order to investigate vestibular morphology, visualised by light microscopy (LM) and transmission electron microscopy (TEM). Contrary to the mix-mice, their littermates showed less stained nerve chalices and it was possible to detect that hair cells showed surface herniations and so-called 'blebs' in the apical portion of the epithelium. Sensory hairs showed a disarrayed pattern. The mix-mice had severe microscopical abnormalities: collapse of the membranous cell layer, cavities inside the neuroepithelium, severe loss of hair cells, herniations of the few remaining hair cells and increased supporting cells were evident. In the utricle and saccule, hair cells were missing and the epithelial surface was covered by a single layer of smooth, flattened epithelial cells of hitherto unknown origin. 2003 S. Karger AG, Basel

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12824731&dopt=Abstract [PubMed - in process]

Biochem Biophys Res Commun. 2002 Oct 4;297(4):818-27.
Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse.

Smith FJ, Porter RM, Corden LD, Lunny DP, Lane EB, McLean WH.

Epithelial Genetics Group, Human Genetics Unit, Department of Molecular and Cellular Pathology, Ninewells Medical School, Dundee DD1 9SY, Scotland, UK.

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Keratin 7 (K7) is expressed in a wide range of epithelial structures in humans. We have cloned and fully sequenced the human and mouse K7 genes and mRNAs, and the K7 mRNA from the marsupial Potorous tridactylis, from which the widely used simple epithelial cell lines PtK1 and PtK2 are derived. Percentage identity plots comparing the mouse and human genomic sequences revealed a number of conserved CpG islands associated with the K7 gene. There was considerable conservation of introns between the two species, which may indicate the presence of intronic regulatory elements. Only the most proximal 500bp of the promoter was conserved, although an additional conserved sequence island was found 2-3kb upstream. Protein sequence comparisons between the three species allowed identification of conserved regions of the keratin variable domains that may be candidates for protein-protein interactions and/or regulatory modification. From the mouse sequence, we generated a polyclonal rabbit antibody specific for murine K7. This antibody was used to perform a survey of K7 expression in the mouse. The expression pattern was similar to the reported human distribution, with substantial expression observed in lung, bladder, mesothelium, hair follicle, and ductal structures. We also noted previously unreported expression of K7 in the gastrointestinal tract and filiform papillae of the tongue and specific K7 expression in a range of "hard" epithelial tissues. The distribution of K7 in mouse and availability of genomic sequence from the 129/Sv mouse strain will allow the generation and analysis of transgenic mice expressing mutant forms of K7 and to predict the phenotype of human genetic disorders caused by mutations in this keratin.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12359226&dopt=Abstract

Int J Circumpolar Health. 2002 Feb;61(1):41-9.
Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury.

Weihe P, Hansen JC, Murata K, Debes F, Jorgensen P, Steuerwald U, White RF, Grandjean P.

Department of Occupational and Public Health, The Faroese Hospital System, Torshavn, Foroe Islands.

Exposure to methylmercury from marine mammals and other seafood may affect the development of the central nervous system. In a traditional Inuit community in Qaanaaq, Greenland, mercury concentrations in cord blood and maternal hair have been examined in connection with all births. We examined 43 children at age 7-12 years with a battery of neurobehavioral tests. The average mercury concentration in hair was 5.0 microg/g and 1.5 microg/g in children and mothers, respectively. Clinical neurological examination did not reveal any obvious deficits. However, neuropsychological tests showed possible exposure-associated deficits, though only in a few cases reaching statistical significance. In conjunction with data from other studies, peak latencies on brainstem auditory evoked potentials tended to be prolonged at increased exposure levels. The data from the present study therefore appears in accordance with other evidence that prenatal or early postnatal exposures to methylmercury may cause subtle neurobehavioral deficits.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12002946&dopt=Abstract

Ginekol Pol. 2000 Sep;71(9):988-92.
[Hyperandrogenism as a frequent cause of hirsutism]

[Article in Polish]

Skalba P, Reczek L, Wojtowicz M.

Excessive hair growth in androgens sensitive areas of female body is called hirsutism and it is a symptom of masculinization. Intensity of hirsutism in particular areas of the body is individual and it depends on the androgens excess rate, or increased sensitivity of hair follicles with normal androgens rate in the serum. There were 84 patients analysed, all of them hospitalized in Department of Gynecological Endocrinology Silesian Medical Academy in Katowice. The aim of this study is to check the correlation between the occurrence and intensity of hirsutism and androgens rate in the serum. In the group of patients with hirsutism the androgens rate was excessed in 72 patients but in 12 women there was an idiopathetical hirsutism diagnosed.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11082962&dopt=Abstract

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