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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs || hair research abs || hair related research references

Magnes Res. 2003 Jun;16(2):98-105.
Protective effect of magnesium and MK 801 on hypoxia-induced hair cell loss in new-born rat cochlea.

Konig O, Winter E, Fuchs J, Haupt H, Mazurek B, Weber N, Gross J.

Department of Otorhinolaryngology, Charite Hospital, Humboldt University, Schumannstrasse 20-21, 10117 Berlin, Germany.

Hypoxia is a pathogenetic factor in various inner ear diseases, and increasing importance is attached to the protection of the cochlea from traumatic influences. It was recently demonstrated in guinea pigs that magnesium can significantly reduce ischemia- and impulse noise-induced hearing loss. The aim of this study was to evaluate if magnesium has a protective effect on hypoxia-induced hair cell loss using an in vitro model of the new-born rat cochlea In view of the NMDA receptor-antagonistic action of magnesium, we tested MK 801, a highly potent and selective non-competitive NMDA receptor antagonist. Organotypic cochlea cultures were exposed to hypoxia (pO2 = 10-20 mm Hg at 37 degrees C) in DMEM medium containing magnesium (0.75 or 3.0 mmol/l) or MK801 (1 or 10 micromol/l) for 24 or 36 h. The cultures were phalloidin-labeled for counting the number of outer and inner hair cells (OHC/IHC). The mean damage in normoxic controls was 1-4%. IHC revealed a significantly higher susceptibility to hypoxia than OHC. In the normal magnesium group (0.75 mmol/l), 36-hour exposure to hypoxia caused a mean loss of about 25% OHC and 60% IHC. In the groups treated with either 3.0 mmol magnesium or 10 microm MK 801, the damage was significantly reduced to about 10% in OHC and 35% in IHC. This study supports previous in vivo observations in the guinea pig demonstrating the protective effects of magnesium on noise-induced impairment of inner ear oxygenation.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12892379&dopt=Abstract [PubMed - in process]

Biol Trace Elem Res. 2003 Jun;92(3):213-20.
Selenium concentrations in human renal cortex, liver, and hair in northern Poland.

Hac E, Krechniak J, Szyszko M, Krzyzanowski M.

Department of Toxicology, Medical University of Gdansk, Al. Gen. Hallera 107, Gdansk, PL 80-416 Poland.

The aim of this study was to (1) determine the selenium concentration in the renal cortex, liver, and hair in 64 residents from northern Poland (Gdansk region) aged 17-81 yr, who died suddenly, and (2) assess whether a correlation between the selenium concentration in hair and in the renal cortex and liver occurs. Selenium was determined by atomic absorption spectrometry using the hydride generation method. The mean selenium concentration in the renal cortex, liver, and hair in the investigated persons was 0.791+/-0.191 microg/g (wet weight), 0.289+/-0.084 microg/g (wet weight), and 0.443+/-0.128 microg/g, respectively. No age-dependent differences in selenium level in the investigated tissues was found. Also, no correlation between the selenium concentrations in hair and in renal cortex and liver was assessed.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12794273&dopt=Abstract [PubMed - in process]

Acta Ophthalmol Scand. 2002 Oct;80(5):543-5.
Primary palpebral and orbital ossification in pseudo-pseudohypoparathyroidism.

Klauber S, Heegaard S, Prause JU.

Eye Pathology Institute, University of Copenhagen, Denmark.

PURPOSE: To present a case of ossification of the eyelid, episclera and orbit in a patient with pseudo-pseudohypoparathyroidism (pPHP). METHODS: A 20-year-old woman diagnosed with pseudo-pseudohypoparathyroidism underwent clinical and histopathological examination of calcified plaques of the right eyelid and orbit. The patient presented with a round face, tousled short hair and retarded speech. She had been diagnosed with pPHP at 3 years of age. During her first decade, calcified plaques developed in the right eyelid and orbit. Gradually, she developed horizontal diplopia, pseudo-ptosis and periorbital pain. Vertical eye movements were reduced to 10 mm, although levator function remained intact. Computer tomography scans of the orbit showed three separate dense structures. Radiographic findings also showed bilateral shortening of the fourth metacarpus and a calcified subcutaneous plaque in the left thigh. The patient's blood status revealed an elevated level of thyroid stimulating hormone, but was otherwise normal. The patient was treated with eltroxin and shortly afterwards regained normal hair and normal speech function. RESULTS: The calcified structures were removed surgically and almost normal eye movements were re-established. Histological examination of the excised tissue demonstrated bone formation. CONCLUSION: This is the first reported case of ossification of the eyelid and orbit in a patient with pseudo-pseudohypoparathyroidism.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12390169&dopt=Abstract

Fa Yi Xue Za Zhi. 2002 Feb;18(1):4-6.
[The expression of FN-IIIcs in the wound healing and its relationship with injury time]

[Article in Chinese]

Ji Y, Zhao ZQ, Gu YJ.

Department of Forensic Medicine of Fudan University, Shanghai 200032.

OBJECTIVE: To research the expression of alternative splicing segment of fibronectin-IIIcs in incised wound of skin, to offer the experimental data for early injury time judgement. METHODS: Using in situ hybridization with DIG-labeled anti-sense RNA probe, the expression of FN-IIIcs domain was detected in both human and rat skin incised wound. RESULTS: (1) The expression of FN-IIIcs improved from the time of 30 min after injury, reached peak at 6 h and then reduced gradually. (2) The positive expression cells were mainly distributed in hair follicles, sebaceous glands and endothelium, however, in human beings they were basement cells of epidermis. CONCLUSION: The expression of FN-IIIcs domain would be a supposed useful criteria for early injury time judgement.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12596577&dopt=Abstract

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