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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs || hair research abs || hair related research references

Hear Res. 2002 Nov;173(1-2):62-8.
Localization of biotinidase in the brain: implications for its role in hearing loss in biotinidase deficiency.

Heller AJ, Stanley C, Shaia WT, Sismanis A, Spencer RF, Wolf B.

Department of Otolaryngology, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298, USA.

Biotinidase deficiency is an autosomal recessively inherited disorder characterized by neurological and cutaneous features, including sensorineural hearing loss. Although many of the features of the disorder are reversible following treatment with biotin, the hearing loss appears to be irreversible. To better characterize the nature of the hearing loss in this disorder, location of the expression and presence of biotinidase within the brain was examined using Northern blot analysis, in vitro hybridization of a cDNA panel, and immunohistochemical staining. Results indicate low, but detectable expression of biotinidase throughout the brain, but increased concentrations of biotinidase within the dorsal cochlear nucleus, ventral cochlear nucleus, and superior olivary complex of the brainstem, as well as, in the hair cells and spiral ganglion of the cochlea. These findings suggest that biotinidase and possibly biotin plays an important role in hearing.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12372635&dopt=Abstract

J Parasitol. 1999 Apr;85(2):354-9.
Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (Aminosidine) and gentamicin.

Grogl M, Schuster BG, Ellis WY, Berman JD.

Department of Biologics Research, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307-5100, USA.

Cutaneous leishmaniasis is presently treated with 20 days of parenteral therapy with a frequently toxic drug (antimony). Topical formulations of paromomycin (15%) plus methylbenzethonium chloride (MBCL, 12%) or plus urea (10%) in soft white paraffin have been tested for Old and New World disease in humans. We compared the efficacy of a new topical formulation, WR 279,396 (paromomycin [15%] plus gentamicin [0.5%]) to the clinical formulations in the treatment of cutaneous disease in BALB/c mice. Sixty-day-old lesions were treated twice a day for 10 days, and the response to therapy was determined over a further 70 days. For ulcers due to Leishmania major or to Leishmania mexicana, 100% of lesions in the WR 279,396 group healed by day 20 after therapy and did not relapse by day 70; 83% of lesions healed without relapse in the paromomycin-MBCL group. In the paromomycin-urea group, 100% of L. major lesions healed by day 30 but 30% relapsed. For ulcers due to Leishmania panamensis or Leishmania amazonensis, all lesions treated with WR 279,396 healed and did not relapse; < 50% of lesions treated with paromomycin-MBCL healed by day 30, and all lesions relapsed by day 70. In addition to being active, WR 279,396 was not toxic in this model and appears to have a cosmetic effect (promoting hair growth, healing, and limiting the size of the scar).

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10219319&dopt=Abstract

Ther Umsch. 2002 May;59(5):238-42.
[Hair loss in internal medical illnesses]

[Article in German]

Fischer TW.

Universitats-Klinik fur Dermatologie und dermatologische Allergologie, Friedrich-Schiller-Universitat Jena, Jena. tobias.fischeerma.uni-jena.de

Hair loss related to internal diseases is generally temporary and often fully reversible. An iron- or protein-deficiency induced hair loss may be cured by simple substitution. In acute internal diseases, fever and after operations the patient may expect complete recovery of the hair loss without therapy. Symptomatic alopecia due to chronic diseases has a different prognosis and is dependent on the severity and character of the underlaying disease. If the systemic disease can be cured the hair loss may be decreased. Treatment and diagnosis of the systemic disease is recommended to be performed in cooperation with experts of internal medicine, oncologists and specialists of endocrinology.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12090121&dopt=Abstract

Environ Res. 2000 Oct;84(2):108-26.
Fish consumption, fish lore, and mercury pollution--risk communication for the Madeira River people.

Boischio AA, Henshel D.

Universidade Estadual de Feira de Santana, Bahia, Brazil.

Fish is an important food resource in Amazonian aquatic ecosystems. There is a strong cultural background regarding fish consumption (fish lore) among indigenous people in the Amazon. Mercury (Hg) ingestion through fish consumption has been a major route of Hg exposure among the riverside people along the Upper Madeira River. In this paper a diet questionnaire was used to identify patterns of fish consumption. The amount of fish consumed during the dry season and Hg levels in fish were combined to estimate Hg ingestion. Using as guidance hair Hg levels below 5 and 10 ppm as acceptable to protect the fetus and adult, respectively, along with an average daily fish consumption of 243 g per capita, we estimated the maximum acceptable number of fish meals per week for different fish species. Based on this analysis, it is suggested that there is a need to address risk communication for this exposed population in the context of health in terms of a fish advisory. For the fish advisory it is necessary to recommend to fish consumers, fishermen, and fish sellers an acceptable number of fish meals to be consumed according to species.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11068924&dopt=Abstract

Due to the complexity , the biological process of hair growth is still a work in progress. Nonetheless, several therapeutic methods including prescription medications, transplant surgery, nutritional suppelements, and even snake oils have been in use to help those who attempt to restore their hair. None of these approaches are perfect due to the heterogeneity in the causes that underlie hair loss. Unfortunately, most of these chemical drugs and hair transplantation operations are accompanied by undesirable side effects.

DHEA has been suggested to provide numerous potential benefits. DHEA (or dehydroepiandrosterone) is converted into androgens (male hormones) or estrogens (female hormones) in the cells.

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