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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs || hair research abs || hair related research references

Am J Human Biol. 2002 Nov-Dec;14(6):707-12.
Association of maturation, sex, and body fat in cardiorespiratory fitness.

Mota J, Guerra S, Leandro C, Pinto A, Ribeiro JC, Duarte JA.

Department of Leisure Sport and Recreation, Faculty of Sport Sciences, University of Porto, Portugal. jmotcdef.up.pt

The aims of this cross-sectional study were 1) to estimate changes in body composition and cardiorespiratory fitness across stages of pubertal maturation, and 2) to describe the relationship between maturity status and body fatness, regional fat distribution, and cardiorespiratory fitness. The sample consisted of 494 children (254 males, 240 females), 8-16 years of age. Height and weight were measured with standard anthropometric methods. Percentage of fat (%F) was estimated from two skinfold thicknesses and regional fat distribution was estimated by the ratio of the subscapular to the triceps skinfold (S/T ratio). Biological maturity was based on self-assessment of breast stages in females and pubic hair stages in males. A maximal multistage 20-m shuttle run was used to predict maximal aerobic capacity from maximal aerobic speed. Both VO(2)max and 20SRT-time were used as indicators of cardiorespiratory fitness. ANCOVA with age as the covariate was used. There were significant differences among girls across pubertal stages. Among boys, only weight and height differed significantly by stage of maturity. When adjusted for maturity status, cardiorespiratory fitness expressed either as VO(2)/kg body mass or 20SRT-time was inversely associated with %F in both sexes. This suggests that sexual maturity status alone accounts for a small portion of the variance in aerobic fitness. Height, %F and the S/T ratio were also significantly associated with VO(2)/kg body mass and 20SRT-time. 2002 Wiley-Liss, Inc.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12400030&dopt=Abstract

Laryngoscope. 2003 May;113(5):791-6.
Branching of spiral ganglion neurites is induced by focal application of fibroblast growth factor-1.

Aletsee C, Brors D, Mlynski R, Ryan AF, Dazert S.

Department o fSurgery-Otolaryngology and Neurosciences, University of California San Diego School of Medicine and Veterans Affairs Medical Center, La Jolla, 92093, USA.

OBJECTIVES/HYPOTHESIS: During the terminal innervation of the developing organ of Corti, fibroblast growth factor-1 (FGF-1) messenger RNA has been shown to be transiently expressed in the sensory epithelium of the rat, suggesting that this growth factor may contribute to developmental processes such as innervation and synaptogenesis of the inner and outer hair cells. In a previous study it has been demonstrated that exogenous FGF-1 supports rat spiral ganglion neurite extension in vitro, whereas a secreted form of FGF-1 produced by transfected fibrocytes induces neurite branching and targeting. STUDY DESIGN: Response of spiral ganglion neurites to FGF-1-coupled beads was compared with the response to noncoupled control beads. METHODS: Effects of multiple focal sources of FGF-1 to outgrowing spiral ganglion neurites were investigated on explants from postnatal day 4 rat spiral ganglion samples that were cultured in the presence of FGF-1 covalently coupled to polybead microspheres. After fixation and immunocytochemical labeling of the explants the growth patterns of the extending neuronal processes were evaluated. RESULTS: When spiral ganglion neurites were observed near clusters of FGF-1 beads, they formed a plexus-like network characterized by significantly higher branching in the vicinity of the beads. However, fibers did not appear to terminate on the beads. Plexus-like formations were not seen at a distance from FGF-1 coupled beads or in the vicinity of control beads lacking FGF-1 on their surface. CONCLUSION: The results of the study indicate that spiral ganglion neurites branch in response to focal sources of FGF-1, suggesting an important role of this growth factor for hair cell innervation during the terminal development of the sensory epithelium.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12792312&dopt=Abstract

Contemp Top Lab Anim Sci. 1998 Jul;37(4):73-75.
Rabbit Fur Mite (Listrophorus gibbus) Infestation of New Zealand White Rabbits.

Niekrasz MA, Curl JL, Curl JS.

Center for Experimental Animal Resources, Northwestern University, Chicago, IL.

The prevalence of Listrophorus gibbus infestation in seven groups of New Zealand White female rabbits that were purchased from the same source was determined by microscopic examination of hair tufts collected from affected rabbits. Thirtynine of 52 (75%) rabbits were infested, although there was variation in the degree of infestation for each group (ranging from 0 to 100%). The infestation did not spread to other rabbits that had been housed in the same room for 72 h. Infested rabbits were treated with a commercially available carbamate-based acaricide, which effectively eliminated infestation with one application ( 3 groups) or two applications at a 5 to 7-day interval (4 groups). Cross-infestation was prevented by use of strict isolation, and eradication was easily accomplished with the use of available acaricides.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12456150&dopt=Abstract [PubMed - as supplied by publisher]

Eur J Biochem. 2002 Dec;269(24):6133-41.
Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.

Sanchez Mas J, Olivares Sanchez C, Ghanem G, Haycock J, Lozano Teruel JA, Garcia-Borron JC, Jimenez-Cervantes C.

Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, Spain.

The alpha-melanocyte-stimulating hormone (alphaMSH) receptor (MC1R) is a major determinant of mammalian skin and hair pigmentation. Binding of alphaMSH to MC1R in human melanocytes stimulates cell proliferation and synthesis of photoprotective eumelanin pigments. Certain MC1R alleles have been associated with increased risk of melanoma. This can be theoretically considered on two grounds. First, gain-of-function mutations may stimulate proliferation, thus promoting dysplastic lesions. Second, and opposite, loss-of-function mutations may decrease eumelanin contents, and impair protection against the carcinogenic effects of UV light, thus predisposing to skin cancers. To test these possibilities, we sequenced the MC1R gene from seven human melanoma cell (HMC) lines and three giant congenital nevus cell (GCNC) cultures. Four HMC lines and two GCNC cultures contained MC1R allelic variants. These were the known loss-of-function Arg142His and Arg151Cys alleles and a new variant, Leu93Arg. Moreover, impaired response to a superpotent alphaMSH analog was demonstrated for the cell line carrying the Leu93Arg allele and for a HMC line homozygous for wild-type MC1R. Functional analysis in heterologous cells stably or transiently expressing this variant demonstrated that Leu93Arg is a loss-of-function mutation abolishing agonist binding. These results, together with site-directed mutagenesis of the vicinal Glu94, demonstrate that the MC1R second transmembrane fragment is critical for agonist binding and maintenance of a resting conformation, whereas the second intracellular loop is essential for coupling to the cAMP system. Therefore, loss-of-function, but not activating MC1R mutations are common in HMC. Their study provides important clues to understand MC1R structure-function relationships.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12473109&dopt=Abstract

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