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Breast Cancer. 2002;9(2):166-9.
Monotherapy with paclitaxel as third-line chemotherapy against anthracycline-pretreated and docetaxel-refractory metastatic breast cancer.

Kinoshita J, Haga S, Shimizu T, Imamura H, Watanabe O, Nagumo H, Utada Y, Okabe T, Kimura K, Hirano A, Kajiwara T.

Department of Surgery, Tokyo Women's Medical University Daini Hospital, 2-1-10 Nishi-ogu, Arakawa-ku, Tokyo 116-8567, Japan. jkinosnh.twmu.ac.jp

We describe a patient with anthracycline-pretreated and docetaxel-refractory metastatic breast cancer who achieved a complete response after third-line chemotherapy with paclitaxel. A 59-year-old woman underwent modified radical mastectomy for advanced cancer in her left breast after local arterial neoadjuvant chemotherapy with anthracycline. Postoperatively anthracycline-containing adjuvant therapy was administered. Pulmonary metastases occurred 15 months after surgery, which did not respond to 4 cycles of second-line chemotherapy with docetaxel, given at 60 mg/m(2) every 3 weeks. Therefore 210 mg/m(2) of paclitaxel was given every 3 weeks as third-line monotherapy and induced a complete response with grade 3 neutropenia and hair loss as the major adverse effects. We suggest that paclitaxel is potentially effective as third-line monotherapy for anthracycline-resistant and docetaxel-refractory metastatic breast cancer.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12016397&dopt=Abstract

J Hyg Epidemiol Microbiol Immunol. 1979;23(1):35-41.
Investigation of the incidence of influenza A viraemia caused by virus strains circulating among children in 1968 - 1977.

Ritova VV, Schastnyi EI, Ratushkina LS, Shuster IY.

Nineteen strains of Type A influenza virus isolated from the blood of small children in 1968--77 were studied. The investigation of the strains in HAIR with antisera to the antigenic components of the strains in HAIR with antisera to the antigenic components of the strains A/Hong-Kong/68,A/Anglia/72, A/Port Chalmers/73 and A/Victoria/75 made it possible to demonstrate antigenic "drive" of the haemagglutinin in the years 1968--1977 and to divide the strains into 4 varieties. A high sensitivity to inhibitors was observed in all the strains isolated. The study of pathogenicity and toxicity of the strains revealed viraemia in the strains isolated during the 1972--1973 epidemic and the subsequent epidemics with the absence of pathogenicity and toxicity for white mice. Regular finding of viraemia coincided in time with increased thermostablty of the haemagglutnin in the strains under study.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=93126&dopt=Abstract

J Comp Neurol. 2000 Nov 27;427(4):508-21.
Nitric oxide synthase localized in a subpopulation of vestibular efferents with NADPH diaphorase histochemistry and nitric oxide synthase immunohistochemistry.

Lysakowski A, Singer M.

Department of Anatomy and Cell Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA. alysakoic.edu

Efferent innervation of the vestibular labyrinth is known to be cholinergic. More recent studies have also demonstrated the presence of the neuropeptide calcitonin gene-related peptide in this system. Nitric oxide is one of a new class of neurotransmitters, the gaseous transmitters. It acts as a second messenger and neurotransmitter in diverse physiological systems. We decided to investigate the anatomical distribution of the synthetic enzyme for nitric oxide, nitric oxide synthase (NOS), to clarify the role of nitric oxide in the vestibular periphery. NADPH diaphorase histochemical and NOS I immunohistochemical studies were done in the adult chinchilla and rat vestibular brainstem; diaphorase histochemistry was done in the chinchilla periphery. Retrograde tracing studies to verify the presence of NOS in brainstem efferent neurons were performed in young chinchillas. Our light microscopic results show that NOS I, as defined mainly by the presence of NADPH diaphorase, is present in a subpopulation of both brainstem efferent neurons and peripheral vestibular efferent boutons. Our ultrastructural results confirm these findings in the periphery. NADPH diaphorase is also present in a subpopulation of type I hair cells, suggesting that nitric oxide might be produced in and act locally upon these cells and other elements in the sensory epithelium. A hypothesis about how nitric oxide is produced in the vestibular periphery and how it may interact with other elements in the vestibular sensory apparatus is presented in the discussion. 2000 Wiley-Liss, Inc.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11056461&dopt=Abstract

Vet Hum Toxicol. 2002 Oct;44(5):260-3.
Blood selenium levels during different stages of selenosis in buffaloes and its evaluation as a diagnostic tool.

Deore MD, Srivastava KA, Sharma SK.

Department of Pharmacology & Toxicology, College of Veterinary Sciences, PAU, Ludhiana, India.

Selenium (SC) toxicity was experimentally induced in male buffalo calves following repeated oral administration of 0.3 mg selenourea/kg (providing 0.19 mg/Se kg) for 75 d. On the basis of the major toxic effects produced in the experimental animals, 10 additional clinical cases of selenosis were identified from field cases. In experimental selenosis blood Se increased from 0.70 +/- 0.08 microg/ml on day 0 to 3.12 +/- 0.01 microg/ml on day 75. Hair Se rose from 2.42 +/- 0.6 ppm on day 0 to 22.91 +/- 2.6 ppm by the 11th w. The erythrocyte glutathione peroxidase (GSH-Px) activity increased from 5.35 +/- 0.94 Eu/mg Hb (0 day) to 18.81 +/- 0.46 EU/mg Hb in the 11th week. Blood Se was of better diagnostic value than hair Se or erythrocytic GSH-Px activity. Signs occurred when Se levels were about 2.0 microg/ml and were prominent above 2.5-2.6 microg/ml: Se levels > or = 1.5-1.75 microg/ml were diagnostic of impending selenosis. The Se concentrations in blood from the field cases of Se toxicity in buffalo had excellent correlation with Se levels in the experimental cases.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12361105&dopt=Abstract

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