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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs || hair research abs || hair related research references

Mol Plant Microbe Interact. 2001 Jan;14(1):55-62.
Early symbiotic responses induced by Sinorhizobium meliloti iIvC mutants in alfalfa.

Lopez JC, Grasso DH, Frugier F, Crespi MD, Aguilar OM.

Instituto de Bioquimica y Biologia Molecular, Universidad Nacional de La Plata, Facultad de Ciencias Exactas, Argentina.

A mutation in the ilvC gene of Sinorhizobium meliloti 1021 determines a symbiotically defective phenotype. ilvC mutants obtained from different S. meliloti wild-type strains are able to induce root hair deformation on alfalfa roots and show variable activation of the common nodulation genes nodABC. All of these mutants are noninfective. The presence of extra copies of nodD3-syrM in an IlvC- background does not promote nod expression but allows the detection of low levels of Nod factor production. The sulphation of the Nod factor metabolites, however, is not affected. Furthermore, IlvC- strains induce a specific pattern of starch accumulation on alfalfa roots as well as of early nodulin expression. Hence, the pleiotropic action of the ilvC gene in S. meliloti may reveal novel complexities involved in the symbiotic interaction.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11194871&dopt=Abstract

J Neurophysiol. 2003 Jun 25 [Epub ahead of print].
Time course and extent of mechanotransducer adaptation in mouse utricular hair cells: Comparison with frog saccular hair cells.

Vollrath MA, Eatock RA.

Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.

Whole-cell transduction currents were recorded from hair cells in early postnatal mouse utricles in response to step deflections of the hair bundle. For displacement steps delivered by a stiff probe (1-ms rise time), half-maximal responses decayed monoexponentially with a mean time constant of 30 ms. Adaptation and other transduction properties did not vary systematically with hair cell type (I vs. II) or region (striola vs. extrastriola). Thus, regional variation in the phasic properties of utricular afferents arises through other mechanisms. When bundles were deflected by a fluid jet, which delivers force steps, transduction currents decayed about three-fold slower than during displacement steps. A simple model of myosin-mediated adaptation predicts such slowing through forward creep of the bundle during a force step. For a faster stiff probe (rise time 200 micro s), step responses of both mouse utricular and frog saccular hair cells decayed with two exponential components, which may correspond to distinct feedback processes. For half-maximal responses, the two components had mean time constants of 5 and 45 ms (mouse) and 2 and 18 ms (frog). The fast and slow components dominated the decay of responses to small and large stimuli, respectively. Adaptation shifts the instantaneous operating range in the direction of the adapting step. In frog saccular hair cells, the operating range shift is a constant percentage of the displacement. In mouse utricular hair cells, the percentage shift increases for large displacements, extending the range of background stimuli over which adaptation can restore instantaneous sensitivity.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12826658&dopt=Abstract [PubMed - as supplied by publisher]

Clin Endocrinol (Oxf). 1975 May;4(3):313-25.
Chronic treatment regimens for hirsutism in women: effect on blood production rates of testosterone and on hair growth.

Casey JH.

Twenty-five women with hirsutism were studied before and during treatment aimed empirically at suppresing testosterone production by adrenals, ovaries or both. Mean basal plasma testosterone was 70 plus or minus 30 ng/dl, significantly (P less than 0.01) higher than the mean of twenty-three normal women; basal metabolic clearance rate (MCR) of testosterone was also higher (P less than 0.01) than that reported for normal women. Production rate (PR) of testosterone exceeded 417 mug/24 h (1 SD above the mean reported for normal women), in nineteen of the twenty-five patients. After 4 months, small dose betamethasone therapy (0.5 mg at bed time) had reduced the mean PR of testosterone in thirteen patients from 509 mug/24 h to 356 mug/24 h (P = 0.05); anovulatory steroids reduced mean PR of testosterone in nine from 612 mug/24 h to 345 mug/24 h (P less than 0.05, greater than 0.025), and the combination of both therapies in ten reduced PR of testosterone from 528 mug/24 h to 148 mug/24 h (P less than 0.001). The latter regimen had moderate success in reducing hair growth (in six out of ten). Fourteen of the twenty-five claimed benefit in hirsutism and all thirteen with acne were improved. In individual cases, clinical benefit did not correlate well with reduction in PR of testosterone. Freedom from undesirable side effects allows these well-accepted forms of treatment to be given even longer trials.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=125164&dopt=Abstract

Plant J. 2003 Jan;33(2):305-17.
GeBP, the first member of a new gene family in Arabidopsis, encodes a nuclear protein with DNA-binding activity and is regulated by KNAT1.

Curaba J, Herzog M, Vachon G.

Laboratoire de Genetique Moleculaire des Plantes, CNRS UMR 5575, Universite Joseph Fourier, CERMO B.P. 53, F-38041 Grenoble Cedex 9, France.

Trichomes of Arabidopsis are single-celled epidermal hair that are a useful model for studying plant cell fate determination. Trichome initiation requires the activity of the GLABROUS1 (GL1) gene whose expression in epidermal and trichome cells is dependent on the presence of a 3'-cis-regulatory element. Using a one-hybrid screen, we have isolated a cDNA, which encodes for a protein, GL1 enhancer binding protein (GeBP), that binds this regulatory element in yeast and in vitro. GeBP and its three homologues in Arabidopsis share two regions: a central region with no known motifs and a C-terminal region with a putative leucine-zipper motif. We show that both regions are necessary for trans-activation in yeast. A translational fusion with the Yellow Fluorescent Protein (YFP) indicates that GeBP is a nuclear protein whose localization is restricted to, on average, 3-5 subnuclear foci that might correspond to nucleoli. Transcriptional fusion with the GUS reporter indicates that GeBP is mainly expressed in vegetative meristematic tissues and in very young leaf primordia. We looked at GeBP expression in plants mutated in or misexpressing KNAT1, a KNOX gene, expressed in the shoot apical meristem and downregulated in leaf founder cells, and found that GeBP transcript level is regulated by KNAT1 suggesting that KNAT1 is a transcriptional activator of GeBP. This regulation suggests that GeBP is acting as a repressor of leaf cell fate.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12535344&dopt=Abstract [PubMed - in process]

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