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Interferon research abs 1 || Hemoglobin research abs || Stem cell research abs || Nucleic acid research abs || Herpes research abs || Bronchitis research abs || Schizophrenia research abs || Tuberculosis research abs || Pneumonia research abs || Constipation research abs || Laxative research abs || hair research abs || hair related research references

Laryngoscope. 2003 Jul;113(7):1216-23.
Noise in magnetic resonance imaging: no risk for sensorineural function but increased amplitude variability of otoacoustic emissions.

Wagner W, Staud I, Frank G, Dammann F, Plontke S, Plinkert PK.

Department of Otorhinolaryngology, University of Tubingen, Elfriede-Aulhorn-Strasse 5, 72076 Tubingen, Germany. w.wagneed.uni-tuebingen.de

OBJECTIVES: Objectives were to perform exact measurements of the noise exposure in a magnetic resonance imager and to investigate the effects of magnetic resonance imaging (MRI) noise on hearing sensitivity, which are still controversial, in a large number of patients. STUDY DESIGN: Prospective trial. METHODS: Acoustic noise during seven different MRI sequences was measured using a custom-made microphone containing no ferromagnetic parts. In 244 ears of 126 patients, pure-tone audiometry was performed once before and once after MRI noise, and distortion product otoacoustic emissions were measured once before and three times after MRI. RESULTS: The sound pressure level (SPL) at the patient's ear (with consideration of the sound-damping effect of the head support) ranged from 79.5 to 86.5 dB (A), depending on the MRI sequence, with brief sound pressure peaks up to 120 dB SPL. No significant incidence of temporary threshold shift and no reduction of mean distortion product otoacoustic emission amplitude were apparent. However, a significant increase in distortion product otoacoustic emission amplitude variability after noise exposure with equal distribution of increased and decreased amplitudes was observed. This variability showed a maximum at 15 minutes after noise, as demonstrated by continuous measurements. CONCLUSIONS: First, MRI noise does not impose a risk to hearing function under the measurement condition of a sound-damping head support or ear protectors. Second, a subtle effect is demonstrated by increased distortion product otoacoustic emission amplitude variability. Third, the increased otoacoustic emission amplitude variability is an audiometric parameter that is extremely sensitive to effects of acoustic stimulation, indicating more discrete changes in cochlear activity than pure-tone audiometry or otoacoustic emission amplitude reduction. A shift of the operation point (OP) of the outer hair cell (OHC) between basilar membrane and tectorial membrane is suggested as underlying cause.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12838022&dopt=Abstract

Chir Ital. 2002 Mar-Apr;54(2):241-4.
Chondroid syringoma. A case report.

Schiano di Visconte M, Picciano P.

Department of Surgery, Hospital of San Dona, Jesolo, Venice.

Chondroid syringoma is a benign skin tumour characterized by several histological aspects similar to salivary gland adenomas. It generally affects the head and neck, mainly in the 6th and 7th decade of life. Its incidence in males is twice as high as in females. The neoplasm is usually an asymptomatic subcutaneous swelling that patients want removed for aesthetic reasons. Excision is the elective treatment. A few cases of malignant chondroid syringoma, however, have been reported. The neoplasm tends to produce metastases to both the regional and distant lymph nodes, causing the death of the patient. In these cases, radiation therapy follows the surgical excision. The authors report the case of a woman with chondroid syringoma located in the occipital region of the scalp. After a period of slow growth, the neoplasm suddenly increased in size. The patient asked for it to be removed out of concern for the concomitant hair loss.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12038117&dopt=Abstract

Forensic Sci Int. 2003 Jun 24;134(1):46-53.
The 2000-2001 GEP-ISFG Collaborative Exercise on mtDNA: assessing the cause of unsuccessful mtDNA PCR amplification of hair shaft samples.

Prieto L, Montesino M, Salas A, Alonso A, Albarran C, Alvarez S, Crespillo M, Di Lonardo AM, Doutremepuich C, Fernandez-Fernandez I, de la Vega AG, Gusmao L, Lopez CM, Lopez-Soto M, Lorente JA, Malaghini M, Martinez CA, Modesti NM, Palacio AM, Paredes M, Pena SD, Perez-Lezaun A, Pestano JJ, Puente J, Sala A, Vide M, Whittle MR, Yunis JJ, Gomez J.

Comisara General de Policia Cientifica, Seccion de Biologia-ADN, Madrid, Spain. biologia.adolicia.es

We report the results of Spanish and Portuguese working group (GEP) of International Society of Forensic Genetics (ISFG) Collaborative Exercise 2001-2002 on mitochondrial DNA (mtDNA) analysis. 64 laboratories from Spain, Portugal and several Latin-American countries participated in this quality control exercise. Five samples were sent to the participating laboratories, four blood stains (M1-M4) and a sample (M5) consisting of two hair shaft fragments. M4 was non-human (Felis catus) in origin; therefore, the capacity of the labs to identify the biological source of this sample was an integral part of the exercise. Some labs detected the non-human origin of M4 by carrying out immuno-diffussion techniques using antihuman serum, whereas others identified the specific animal origin by testing the sample against a set of animal antibodies or by means of the analysis of mtDNA regions (Cyt-b, 12S, and 16S genes). The results of the other three human blood stains (M1-M3) improved in relation to the last Collaborative Exercises but those related to hairs yielded a low rate of success which clearly contrasts with previous results. As a consequence of this, some labs performed additional analysis showing that the origin of this low efficiency was not the presence of inhibitors, but the low quantity of DNA present in these specific hair samples and the degradation.As a general conclusion the results emphasize the need of external proficiency testing as part of the accreditation procedure for the labs performing mtDNA analysis in forensic casework.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12842357&dopt=Abstract [PubMed - in process]

Ann Otol Rhinol Laryngol. 1978 Jan-Feb;87(1 Pt 1):70-80.
Intercellular junctions in the organ of Corti.

Nadol JB Jr.

The intercellular junctions between adjacent supporting cells and between apposed hair and supporting cells in the organ of Corti of cat and human were studied. At the endolymphatic surface, the intercellular space was closed by a series of tight junctions (zonula occludens), whereas there were no tight junctions at the basilar membrane surface of the neuroepithelium. Beneath the adlumenal zonula occludens between adjacent supporting cells, a zonula adherens (intermediate junction, "desmosone") was found. Many gap junctions joined apposed supporting cells both within apposed hair and supporting cells, membrane specialization sharing the morphological characterics of both the macula adherens and zonula adherens was found. Between cells, there were short areas of parallel limiting membranes separated by a 20A intercellular space. These areas were suggestive but not characteristic of gap junctional specialization. The functional significance of the junctional specialization between cells in the organ of Corti is discussed.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23719&dopt=Abstract

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