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References: Hair growth and hair loss

Dermatol Surg. 1998 Oct;24(10):1065-8.
Experience with laser hair transplantation in Orientals.

Tsai RY, Chen DY, Chan HL, Ho YS.

Department of Dermatology and Laser Center, Taipei Municipal Wan-Fang Hospital, Taiwan.

BACKGROUND: The advent of high-energy carbon dioxide (CO2) laser-assisted hair transplantation in recent years provides a new recipient area technique for hair restoration surgery. It offers the advantages of less bleeding, time consumption, and graft compression. Specific laser parameters have been recommended in Caucasian but not Oriental patients. OBJECTIVE: To determine the effectiveness as well as appropriate parameters of laser hair transplantation in Oriental patients. METHODS: A Sharplan SilkTouch laser with the Flashscanner set to produce a 0.8-1-mm recipient site hole was employed for all subjects. Various CO2 laser parameters were used to compare the graft survival rate with traditional Nokor needle or microdilator methods for micrografting on each side of the scalp. A total of 20 patients joined the study in the past 18 months. A skin biopsy was performed to examine the tissue effect of the different laser parameters. RESULTS: Hair survival was less than that seen with conventional micrografting techniques in the first five cases, in whom CO2 laser parameters of 36-40 W and 0.2-0.7 seconds were used. After adjusting the parameters to 55 W and 0.1-0.15 seconds, the survival rate increased to between 80% and 90%. In addition, most patients thought the laser-prepared sites resulted in a more natural appearance and better hair density, when they were compared with conventionally prepared sites. CONCLUSIONS: From our study, we find that CO2 laser parameters of 55 W and 0.1-0.15 seconds seem to be the appropriate parameters for Oriental hair transplant patients. Further studies are required to establish laser parameters that will produce better hair survival.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9793515&dopt=Abstract

Br J Oral Maxillofac Surg. 2001 Aug;39(4):289-93.
Immunohistochemical localization of bone morphogenetic protein-2 in the oral and maxillofacial area of the human embryo.

Suzuki T, Bessho K, Segami N, Iizuka T, Nojima T.

Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan.

The purpose of this study was to investigate the bone morphogenetic protein-2 (BMP-2) expression in oral and maxillofacial tissue of the human embryo. A human embryo was obtained from a patient with hysterorrhexis. The oral and maxillofacial area of the embryo was analyzed immunohistochemically using specific antibodies to BMP-2. BMP-2 was found mainly localized in developing teeth buds, jaw bone, striated and smooth muscle, spinal cord and nasal tracheal and oesophagal epithelium. However, it was not found in hair follicles. These findings are similar to those of BMP-2 and -4 gene expression in mouse and rat embryos. BMP-2 may be involved in the morphogenesis of oral and maxillofacial tissue in human embryos as well as those of other animals. These results will be of considerable benefit in the restoration and regeneration of the oral and maxillofacial tissue clinically. Copyright 2001 The British Association of Oral and Maxillofacial Surgeons.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11437427&dopt=Abstract

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BACKGROUND: The purpose of surgery is to effect functional and/or cosmetic benefit while causing as few adverse consequences as possible. At its core lies incision/excision, tissue mobilization, and reconstruction. Each body region presents its own particular surgical challenge. Scalp is made up of collagen, elastin, blood vessels, nerve fibers, and lymphatics with mucopolysaccharide ground substance and tissue fluid, together with hair follicles, sweat, and sebaceous glands. All these elements are anatomically and biologically affected by each modality of surgery. OBJECTIVE: To establish technical guidelines for scalp surgery compatible with maximal functional/cosmetic benefit and complication-free results. METHODS: More than 3000 scalp operations done personally were reviewed. These included the entire spectrum of plastic and reconstructive surgery and hair restoration procedures. RESULTS: Some guidelines compatible with improved scalp surgery results were derived. CONCLUSION: Complication-free scalp surgery is most likely to occur when incisions spare neurovascular structures; do not transect collagen or elastin; undermining is modest and discriminate; deep plane fixation is used; and hair directional orientation (drape) is preserved.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11553172&dopt=Abstract

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