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References: Hair growth and hair loss

Br J Ophthalmol. 1995 Nov;79(11):1003-6.
Inferior retractor plication surgery for lower lid entropion with trichiasis in ocular cicatricial pemphigoid.

Elder MJ, Dart JK, Collin R.

Moorfields Eye Hospital, London.

AIMS--To assess the outcome of inferior retractor plication surgery for lower lid entropion in patients with ocular cicatricial pemphigoid (OCP). This technique avoids surgery on the conjunctiva that can result in exacerbations of disease activity. METHODS--This prospective study assessed the outcomes of a standard 'Jones' type plication in 14 lids of 10 patients with OCP. Seven patients were taking systemic immunosuppression and no patients had conjunctival inflammation for the 4 months before surgery. RESULTS--Life table analysis showed a 77% chance of anatomical success at 2 years and a 54% chance of completely preventing lash-globe touch. The surgery did not cause clinical activation of conjunctival inflammation or other complications. Anatomical failure was primary (n = 2) and due to late cicatrisation (n = 1). Three further cases had restoration of normal anatomy but the patients had persistently misdirected lashes that touched the globe. CONCLUSION--This technique gives good anatomical success over long periods and is particularly safe when there is no conjunctival inflammation present before surgery.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8534641&dopt=Abstract

Clin Exp Dermatol. 1995 Mar;20(2):127-31.
Oral cyclosporin A restores hair growth in the DEBR rat model for alopecia areata.

Oliver RF, Lowe JG.

Department of Biological Sciences, University of Dundee, UK.

The Dundee experimental bald rat (DEBR) undergoes hair loss associated with the development of peri- and intrafollicular mononuclear cell infiltrates, as occurs in human alopecia areata. We studied the effect of orally administered cyclosporin A (10 mg/kg; 5 days/week for 7 weeks) on established lesional DEBR rats displaying extensive areas of hair loss. New hairs appeared after 10 days and there was simultaneous regrowth of hair over the whole body with restoration of a full pelt by 5 weeks. Semiquantitative histological examination of flank skin biopsies revealed early reduction of the cellular infiltrate associated with conversion of dystrophic anagen follicles to normal, hair-producing follicles. These results confirm the value of the DEBR model of alopecia areata in evaluating existing and new therapies for this disease in humans.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8565246&dopt=Abstract

Dermatol Surg. 1996 Feb;22(2):161-73; discussion 173-4.
Planning for maximum coverage in surgical hair restoration.

Unger WP.

BACKGROUND. Previous articles in this publication have suggested that an isolated frontal forelock is probably the best objective for a majority of patients undergoing hair transplantation. OBJECTIVE. This communication disputes the advisability of an isolated frontal forelock for a majority of hair transplant patients. METHODS. Previous studies and publications indicate a relatively low incidence of extensive male pattern baldness. Newer harvesting techniques require relatively small donor a areas to yield large numbers of grafts. Alopecia reduction can significantly improve the donor/recipient area ratio, and minigrafting can produce very natural looking results with less donor graft utilization. All of the preceding are presented to support the position of the author. RESULTS. Limiting oneself to an isolated frontal forelock is an overly conservative objective for a sizable majority of patients. CONCLUSION. The isolated frontal forelock is a wise goal for a minority of patients who should be chosen on the basis of their limited objectives as well as their family history and a careful physical examination at the time of presentation. For most patients, more extensive coverage remains a reasonable option.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8608379&dopt=Abstract

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