References: Hair growth and hair loss
Rev Elev Med Vet Pays Trop. 1992;45(1):39-41.
Ivomec, a treatment against rabbit mange.
Nfi AN.
Institute of Animal Research, Bamenda, Cameroun.
The trial with Ivomec as a treatment against sarcoptic mange in rabbits gave very encouraging results. There was 100% clinical recovery in 31 rabbits that were treated with no cases of reinfestation. Even though there was no significant difference (P > 0.05) in weight gain between the treated and untreated groups, the efficacy of Ivomec was visually appreciated. Pruritus ceased one week post-treatment while total hair regrowth occurred after 6 weeks.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1298025&dopt=Abstract
J Clin Endocrinol Metab. 1992 Feb;74(2):345-50.
Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque.
Diani AR, Mulholland MJ, Shull KL, Kubicek MF, Johnson GA, Schostarez HJ, Brunden MN, Buhl AE.
Upjohn Laboratories, Kalamazoo, Michigan 49001.
A 5 alpha-reductase inhibitor, finasteride, was administered orally at 0.5 mg/day, alone or in combination with topical 2% minoxidil, for 20 weeks to determine the effects on scalp hair growth in balding adult male stumptail macaque monkeys. A 7-day dose-finding study showed that both 0.5- and 2.0-mg doses of the drug produced a similar diminution in serum dihydrotestosterone (DHT) in male stumptails. Hair growth was evaluated by shaving and weighing scalp hair at baseline and at 4-week intervals during treatment to obtain cumulative delta hair weight (sum of the 4-week changes in hair weight from baseline) for the 20-week study. The activity of the 5 alpha-reductase enzyme was assessed by RIA of serum testosterone (T) and DHT at 4-week intervals. The combination of finasteride and minoxidil generated significant augmentation of hair weight (additive effect) compared to either drug alone. Finasteride increased hair weight in four of five monkeys. When the data of the one nonresponsive monkey were excluded, finasteride elicited a significant elevation in hair weight compared to topical vehicle alone. Minoxidil also evoked a significant increase in hair weight compared to vehicle alone. Serum T was unchanged, whereas serum DHT was significantly depressed in monkeys that received either finasteride or the combination of finasteride and minoxidil. These data suggest that inhibition of the conversion of T to DHT by this 5 alpha-reductase inhibitor reverses the balding process and enhances hair regrowth by topical minoxidil in the male balding stumptail macaque.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1309834&dopt=Abstract
Br J Dermatol. 1976 Mar;94 suppl 12:51-8.
The place of intralesional steroid therapy in dermatology.
Verbov J.
Intralesional steroid therapy has a definite, if small, place in dermatology and triamcinolone acetonide is the preparation in most common use. Such therapy may be used, particularly in nail disorders, keloids and hypertrophic scars, cystic acne, and to speed regrowth of hair in localized alopecia areata. Other conditions in which it has a place include cutaneous lupus erythematosus and sarcoidosis. There are some conditions where use is occasionally indicated and yet others where further trial is merited.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=131575&dopt=Abstract
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