References: Hair growth and hair loss
Neuroscience. 1998 Mar;83(1):43-61.
Plasticity of cerebral metabolic whisker maps in adult mice after whisker follicle removal--II. Modifications in the subcortical somatosensory system.
Melzer P, Smith CB.
Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892-4030, USA.
The follicles of whiskers C1-3 were removed from the left side of the snout of adult mice. Adjacent whiskers B1-3 and D1-3 were stimulated while local rates of glucose utilization were measured with the [14C]2-deoxyglucose method two, four, eight, 64, 160 and approximately 250 days after follicle removal. Local metabolic activity in the trigeminal sensory brainstem and somatosensory thalamus was compared with that of unoperated mice with the same stimulation and of mice with the same lesion that had all whiskers clipped. Actual rates of glucose utilization were measured in brainstem subnuclei caudalis and interpolaris whereas metabolic activation was only assessable by colour-coded imaging in brainstem nucleus principalis and in the thalamic ventrobasal complex. Whisker stimulation activated the somatotopically appropriate loci in brainstem and thalamus. In addition, the territory deprived by follicle removal was metabolically activated in subnuclei caudalis and interpolaris at all time intervals examined. The activation was statistically significant in subnucleus interpolaris at two days, indicating that the metabolic representations of whiskers neighbouring the lesion rapidly expanded into the deprived territory. Nucleus principalis showed a broad metabolic activation at two and four days that was absent at the longer time intervals examined. Instead, at approximately 250 days the metabolic representations of the whiskers adjacent to the lesion were enlarged into the deprived territory as in the subnuclei. Since metabolic whisker representation in the ventrobasal complex appeared to have changed in the same fashion, follicle removal apparently resulted in congruent modifications of the whisker map in the three nuclei of termination as well as in the thalamic relay at the longest time interval examined. Since metabolic responsiveness of the deprived barrels in barrel cortex of the same animals increased statistically significantly only several months after follicle removal, the novel neural responses in the brainstem were not effectively transmitted to barrel cortex immediately and the slowly evolving cortical modifications are more likely to be associated with regrowth of the connectivity of primary neurons. By contrast, unmasking of hitherto suppressed inputs may underlie the early expansion of metabolic whisker representation in the brainstem.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9466398&dopt=Abstract
J Burn Care Rehabil. 1998 Jan-Feb;19(1 Pt 1):10-7.
Cutaneous nerve distribution in adult rat hairy skin after thermal injury--an immunohistochemical study.
Ward RS, Tuckett RP, English KB, Johansson O.
Division of Physical Therapy, University of Utah School of Medicine, Salt Lake City, USA.
Regrowth of cutaneous nerves after thermal injury was examined in rat hairy skin with use of protein gene product 9.5, which has been shown to label nerves in skin preparations. Tissue biopsies were obtained from injured and control skin at postburn days 1, 7, 14, 28, and 120, fixed in 4% paraformaldehyde, cryoprotected, sectioned, and immunostained with rhodamine conjugated goat anti-rabbit immunoglobulin G. Immunoreactivity for protein gene product 9.5 was intense and illustrated the process of nerve regrowth in rat skin after thermal injury. No nerve growth was detectable in 1- and 7-day preparations. Variable regeneration was noted in 14-day preparations. The 28- and 120-day groups produced nerve counts that were similar to control sections. Results suggest that rat hairy skin has a capacity for nerve regrowth after thermal injury. Nerves were noted to regenerate from beneath the scar. Burn wounds in rats demonstrated vigorous cutaneous nerve regeneration.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9502018&dopt=Abstract
Ann Plast Surg. 1999 Mar;42(3):249-54.
The effect of ruby laser light on ex vivo hair follicles: clinical implications.
Liew SH, Grobbelaar AO, Gault DT, Sanders R, Green CJ, Linge C.
RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood, Middlesex, UK.
Several clinical studies on the efficacy of ruby laser-assisted hair removal have reported that regrowth of hair after treatment is common. One of the reasons for the regrowth of hair is the incomplete destruction of germinative hair cells due to the insufficient penetration of the ruby laser in the skin. It was the aim of this study to estimate the extent of damage to the hair follicles after one ruby laser treatment and to determine whether the ruby laser destroyed the bulbs and the bulge regions of hair follicles. The extent of laser damage in hair shafts was determined by serial examination of six specimens of ex vivo scalp skin lasered with the Chromos 694 Depilation Ruby Laser at 14 J per square centimeter and 20 J per square centimeter. Another nine specimens of ex vivo scalp skin were similarly lasered, and monoclonal antibody LP2K was used to identify the bulge regions of the hair follicles using the immunoperoxidase technique. Damage to the bulge region was assessed from consecutive specimens, which were stained with hematoxylin-eosin stain. The mean depth of laser damage sustained by hair follicles was 1.34 mm (14 J per square centimeter) and 1.49 mm (20 J per square centimeter) underneath the skin surface. Most of the laser damage involved the bulge regions but fell short of the hair bulbs. The laser damage did not seem to extend far enough down the hair shafts to result in permanent hair destruction. The clinical implications of this finding are discussed.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10096614&dopt=Abstract
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