References: Hair growth and hair loss
East Afr Med J. 1994 Oct;71(10):674-5.
Intralesional triamcinolone acetonide in alopecia areata amongst 62 Saudi Arabs.
Kubeyinje EP.
Arar Central Hospital, Kingdom of Saudi Arabia.
Evaluation of 62 Saudi Arabs with alopecia areata on monthly intralesional injection of triamcinolone acetonide, showed complete regrowth in 40 (63%) patients at 4 months. Regrowth was likely in young adults with few lesions (less than 5 patches), lesions of short durations (less than 1 month) patches less than 3 cm in diameter. Regrowth was poor when associated with atopy (2 patients) and mongolism (1 patient). Side effects of treatment were minimal and the drug was well tolerated.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7821250&dopt=Abstract
J Invest Dermatol. 1994 Jul;103(1):122-6.
Use of gamma-glutamyl transpeptidase activity as a marker of hair cycle and anagen induction in mouse hair follicles.
Kawabe TT, Kubicek MF, Johnson GA, Buhl AE.
Biochemistry Research, Upjohn Company, Kalamazoo, Michigan 49007.
gamma-glutamyl transpeptidase activity was monitored in cycling mice by histologic localization and biochemical assay. Our objective for this study is to establish the relationship between gamma-glutamyl transpeptidase activity and hair growth and to determine whether its activity can be correlated to induced hair growth. In cycling mouse skin, gamma-glutamyl transpeptidase activity is pronounced during anagen and greatly diminished during telogen. In the skin, the enzyme is present exclusively in the outer and inner root sheaths of hair follicles. gamma-glutamyl transpeptidase is limited to the follicle below the level of the sebaceous gland and is completely absent in the follicle above the sebaceous gland level. During anagen, the outer root sheath in the hypodermis is intensely positive for gamma-glutamyl transpeptidase activity whereas the hair matrix cells and dermal papillar are negative. The inner root sheath above the bulb shows distinctive membrane staining for gamma-glutamyl transpeptidase. gamma-glutamyl transpeptidase activity can be seen to vary only in cycling follicles. Inducing anagen by plucking hair shafts results in an increase in gamma-glutamyl transpeptidase activity directly correlated to hair regrowth. In a similar manner, mice were plucked and treated with a daily dose of 2% minoxidil. A slight difference in cycle lengths was seen in animals treated with minoxidil when compared to vehicle control. Minoxidil treatment may cause an early initiation of anagen, but both the minoxidil-treated skin and the vehicle-treated skin entered telogen at the same time. Together, these studies indicate that gamma-glutamyl transpeptidase is a specific marker of anagen in growing hair.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7913117&dopt=Abstract
Jikken Dobutsu. 1994 Jul;43(3):417-20.
Corneal dermoid in two laboratory beagle dogs.
Horikiri K, Ozaki K, Maeda H, Narama I.
Research Institute of Drug Safety, Setsunan University, Osaka, Japan.
Two male laboratory beagle dogs used in toxicity studies, one 7 months old and the other 9 months old, showed the evidence of corneal dermoid. Grossly, the dermoid was observed in both cases as hair growth from the cornea. In one case, the hairs had been removed from the cornea, but regrowth was observed about 70 days later. Histopathologically, melanocytes, melanin granules, hairs, hair bulbs, adipose tissue and sebaceous and sweat glands were observed in the corneal epithelium and propria. According to the information obtained from 4 breeders, the incidence of corneal dermoid was extremely rare in laboratory beagle dogs.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7925632&dopt=Abstract
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