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References: Hair growth and hair loss

J Exp Zool. 1995 Aug 15;272(6):435-45.
Seasonal fiber growth cycles of ferrets (Mustela putorius furo) and long-term effects of melatonin treatment.

Nixon AJ, Ashby MG, Saywell DP, Pearson AJ.

Ruakura Research Centre, Hamilton, New Zealand.

Pelage cycles of ferrets are poorly documented, although it is clear that their timing is sensitive to daylength, mediated by pineal melatonin. Hair follicles were monitored histologically in ferrets from 3 to 19 months of age in order to describe naturally occurring changes in follicle growth status and follicle number over three successive cycles of fur growth. Melatonin was administered to some of these animals in late summer to determine the long-term effects of perturbation of hormonal control. Circulating melatonin was elevated for approximately 50 days by 8-mg continuous release implants. Treated animals grew both their first winter coat, and subsequent summer coats 18 days in advance of untreated controls, but this effect did not extend to the second winter coat. Reimplantation the following year induced an advancement of the autumn follicle growth as in the 1st year. Autumn fiber growth occurred at similar times in untreated males and females, and response to melatonin did not differ between sexes. Hair follicle regression and shedding during the natural spring molt was also contemporaneous in males and females, but fiber regrowth occurred 4-6 weeks later in males as compared with females, suggesting that reproduction-related factors affect fiber growth initiation, and that fiber growth and shedding are physiologically distinct processes. Melatonin implants in autumn also affected reproduction in the spring, advancing oestrus by 3-4 weeks. These results show that interference with photoperiodic and hormonal control mechanisms in ferrets can affect pelage and reproductive cycles for up to 10 months.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7673877&dopt=Abstract

Dermatol Surg. 1995 Apr;21(4):312-3.
Regrowth of grafted human scalp hair after removal of the bulb.

Kim JC, Choi YC.

Department of Immunology, School of Medicine, Kyung-pook National University, Taegu, Seoul, Korea.

BACKGROUND. The bulbar region of the hair follicle contains the dermal papilla, hair germinative epithelial component, and active melanocytes. Thus, it has been assumed that the bulbar region plays a central role in hair growth, differentiation, and pigmentation. OBJECTIVE. To assess the regenerative capacity of human hair. METHODS. Individual anagen hair follicles were isolated from the occipital scalp and grafted onto the leg after removal of the bulb. RESULTS. The grafts of follicles from which the bulb and complete papilla have been excised regenerated new papillae and grew new pigmented hairs. CONCLUSION. The middle portion of the outer root sheath and dermal sheath may also contain epithelial, mesenchymal, and melanocyte reservoirs.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7728481&dopt=Abstract

Br J Ophthalmol. 1994 Oct;78(10):769-71.
Cryotherapy for trichiasis in ocular cicatricial pemphigoid.

Elder MJ, Bernauer W.

Moorfields Eye Hospital, London.

Trichiasis is a common and potentially sight threatening complication of ocular cicatricial pemphigoid and is usually secondary to cicatricial entropion. This study aimed to assess the success and complications of eyelid cryotherapy for trichiasis in a group of patients with long term follow up. The case records of all patients with ocular cicatricial pemphigoid that attended the external disease clinic at Moorfields Eye Hospital from 1980 to 1992 were reviewed. Each eyelid was divided into three horizontal zones. Cryotherapy was delivered with an Amoilette cryoprobe for approximately 30 seconds. Failure of the cryotherapy was defined as a regrowth of the eyelashes within the treated zone that either required epilation for symptom control or caused keratopathy. Ninety two lid zones were treated, involving 25 lids of 12 patients. The cumulative chance of success decreased rapidly to 40% over the first year. Thereafter, the chance of success declined slowly to 34% at 4 years. Complications included lid notching (n = 2), tarsal atrophy (n = 1), altered lid contour (n = 1), and temporarily raised intraocular pressure (n = 1). All patients had quiescent disease at the time of the cryotherapy and no patients showed increased conjunctival disease activity after treatment. Six patients were taking systemic immunosuppression medication. When ocular cicatricial pemphigoid is quiescent, lid cryotherapy has an acceptable complication rate. The major reason for recurrence of the trichiasis was attributed to inadequate follicle freezing.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7803353&dopt=Abstract

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