References: Hair growth and hair loss
Arch Dermatol. 1984 Apr;120(4):457-63.
Alopecia areata treated with topical minoxidil.
Weiss VC, West DP, Fu TS, Robinson LA, Cook B, Cohen RL, Chambers DA.
A 1% minoxidil topical solution was used to treat 48 patients with alopecia areata, ie, 24 patients with patchy disease and 24 patients with alopecia totalis or alopecia universalis. Twenty-five patients had terminal hair regrowth; in 11 of the 25 patients, it was cosmetically acceptable. No clinical features of the disease seemed to indicate the likelihood of hair regrowth. Hair regrowth began approximately two months after the initiation of treatment and was not uniformly well maintained after the treatment was terminated. One patient had an allergic contact dermatitis reaction to the minoxidil solution; no systemic side effects were seen. No notable systemic absorption was found in 18 adult patients. Effects on cutaneous blood flow or the immune system or some direct effect on hair follicles are possible mechanisms by which minoxidil therapy might stimulate hair growth.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6703751&dopt=Abstract
J Invest Dermatol. 1983 Jul;81(1):31-8.
The thymus dependency of acquired resistance to Trichophyton mentagrophytes dermatophytosis in rats.
Green F 3rd, Weber JK, Balish E.
Congenitally athymic "nude" (RNU/RNU) rats and euthymic (+/RNU) rats were cutaneously inoculated with Trichophyton mentagrophytes. Dermatophytosis, as evidenced by erythema and scaling, was observed in both athymic and euthymic rats by day 7 postinfection. Macroscopic lesions in +/RNU rats became intensely erythematous (climax days 10-14), were limited in spread and alopecia (days 16-20), and healed with hair regrowth by day 35. In nude rats, however, erythema peaked early (days 8-10) and a persistent, mild erythema and scaling spread over the animals' backs. Viable T. mentagrophytes was cultured from the skin of all infected nude rats for the duration of each experiment (90 days), while +/RNU rats became culture-negative by day 35. Following clearance of primary lesions, +/RNU rats manifest a delayed-type hypersensitivity skin test response to soluble trichophytin and an accelerated cutaneous inflammation and enhanced resistance to reinfection. Although T. mentagrophytes primarily invaded the keratinized layers of the epidermis in both nude and +/RNU rats, hyphae and arthrospores were also observed within the nucleated layers of the internal root sheath of hair follicles. Our observations are consistent with the hypothesis that thymus-dependent cell-mediated immunity is required to limit cutaneous spread and terminate cutaneous T. mentagrophytes infection. This acquired immunity against T. mentagrophytes in +/RNU rats was characterized histologically by: (1) an intense inflammatory migration of lymphocytes, monocytes, and macrophages into the epidermis, dermis, and follicular epithelium; (2) hyperplasia of the epidermis and follicular epithelium; and (3) elimination of arthrospores and hyphae from T. mentagrophytes-infected skin.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6863978&dopt=Abstract
J Invest Dermatol. 1982 Sep;79(3):197-200.
Changes in the proteins of wool following treatment of sheep with epidermal growth factor.
Gillespie JM, Marshall RC, Moore GP, Panaretto BA, Robertson DM.
Administration of epidermal growth factor (EGF) extracted from mouse submaxillary gland to Merino sheep resulted in a temporary inhibition of the activity of the wool follicles. Subsequently, either complete discontinuities appeared in the fibers resulting in shedding of the entire fleece, or incomplete, in which case the fleece was retained but bore a zone of weakness. The protein composition of the first sample of wool harvested from 1 sheep following infusion for 66 hr with 27.5 mg EGF (0-2 weeks posttreatment) was similar to pretreatment wool. This represented wool fibers which were already present in the follicles at the beginning of infusion. Thereafter, the composition of the wool changed progressively, reaching a maximum divergence from the control in the 3-4 week regrowth period followed by a return to normal by about 10 weeks. Over this period the content of high-sulfur proteins first rose from an initial 19% to a maximum of 30%, then returned to 19%, while the high-tyrosine protein content initially decreased from 12% to 5% and then slowly increased to 12%. In addition to changes in overall protein composition, two-dimensional electrophoresis revealed alterations in the proportions of some individual protein components. These changes were similar to those observed with many other wool growth inhibitors. Smaller doses of EGF (5.8 and 2.9 mg but not 1 mg) had similar effects on wool composition but these were of lower magnitude and there was a delay in reaching a maximum response. Even after 16-18 weeks the wool from these treated sheep differed slightly in composition from the pretreatment samples.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6980955&dopt=Abstract
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