References: Hair growth and hair loss
Int J Dermatol. 1985 Nov;24(9):608-10.
Treatment of alopecia areata with topical nitrogen mustard.
Arrazola JM, Sendagorta E, Harto A, Ledo A.
Eleven patients with severe alopecia areata (localized and totalis types) were treated with topically applied nitrogen mustard. Nine patients had terminal hair regrowth; in 7 of the 11 patients, it was cosmetically acceptable. Hair regrowth began approximately 1-2 months after the initiation of therapy. Two patients had an allergic contact dermatitis reaction to the mechloretamine solution; no systemic side effects were seen. During a follow-up period of 12 months, only two patients had a recurrence. These preliminary results indicate that topically applied nitrogen mustard has a significant effect in alopecia areata.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4066107&dopt=Abstract
J Immunol. 1979 Aug;123(2):947-8.
Genetic mapping of the locus controlling structural variations of murine C3 in the chromosome 17.
Natsuume-Sakai S, Hayakawa J, Amano S, Takahashi M.
Backcross progeny, (NC X TF/GnLe)F1 X TF/GnLe, was tested for C3 allotype controlled by C3-1 and the expression of mutant gene tf, repeated loss and regrowth of hair. The recombination frequency between these two loci both located in chromosome 17 of the mouse was 24%. Taken together with our previous linkage data, C3-1 is now localized to a position 11 cm more distal than H-2 on chromosome 17.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=458159&dopt=Abstract
Z Hautkr. 1977 Nov 15;52(22):1129-34.
[Alopecia areata: successful half-side treatment with DNCB]
[Article in German]
Happle R, Echternacht K.
In 46 patients with alopecia areata, one side of the head was treated with weekly applications of DNCB, dissolved in acetone. The therapeutic aim was mild contact dermatitis. The other side of the head served as control region. A therapeutic effect was noted in 36 patients: 22 patients showed regrowth of hair exclusively on the treated side, and in 14 patients regrowth of hair was considerably faster and more dense on the treated side. In 8 patients no regrowth was observed, and in 2 patients regrowth occurred on both sides without any difference of intensity. The difference between both sides with regard to hair growth was seen in all of the 7 patients with moderate involvement and in 12 out of 13 patients with extensive involvement; but also in 17 out of 26 patients with alopecia areata totalis or fere totalis. The difference was noted, in the majority of cases, within 3 months. These results prove the efficacy of DNCB treatment of alopecia areata.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=595747&dopt=Abstract
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