References: Hair growth and hair loss
J Am Acad Dermatol. 1987 Mar;16(3 Pt 2):657-68.
Action of topical minoxidil in the bald stump-tailed macaque.
Uno H, Cappas A, Brigham P.
The effect of topical minoxidil (5% and 2% solutions) on hair regrowth was studied in the frontal bald scalp of 18 adolescent and adult stump-tailed macaques (Macaca arctoides). Gross observation of the hairiness and folliculogram analysis of the skin biopsy specimens have shown that minoxidil induces the enlargement of vellus follicles to the size of middle to terminal follicles (regrowth of hair effect), minoxidil maintains the terminal follicles in the prebald scalp of periadolescent animals (prevention of baldness effect), enlarged follicles regress after minoxidil is withdrawn, and hair follicular growth is once again stimulated when treatment with minoxidil is reinstituted. Hair regrowth was more prominent in the early stage of baldness among younger macaques than in baldness of longer duration in older animals. An in vitro study of 3H thymidine uptake revealed that the hair follicles in minoxidil-treated macaque skin showed significant enhancement of deoxyribonucleic acid synthesis in the follicular and perifollicular cells but not in the epidermal keratinocytes. Furthermore, the uptake of 3H minoxidil and its conversion to minoxidil sulfate (the active metabolite producing vasodilation) was relatively higher in the hair follicles than in the epidermis and dermis. Serum concentration of minoxidil was fairly constant 2, 4, 6, 15, and 24 hours after a single application (averaging 15 ng/ml with 5% minoxidil). Minoxidil's essential action in hair follicular growth may be as a potent vasodilator. However, a direct action on the hair follicle cannot be ruled out considering uptake and conversion of the drug to minoxidil sulfate within the hair follicle itself.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3558911&dopt=Abstract
J Am Acad Dermatol. 1987 Mar;16(3 Pt 2):685-7.
Use of topical minoxidil as a possible adjunct to hair transplant surgery. A pilot study.
Kassimir JJ.
Twelve patients, aged 21 to 60 years, with varying Hamilton classifications of androgenetic alopecia (male pattern baldness) were treated with a 3% solution of topical minoxidil. Therapy began 48 to 72 hours after hair transplant surgery. Two patients demonstrated hair growth in the grafts without the shedding that usually occurs 2 to 4 weeks after surgery. (In untreated patients after hair transplant surgery, regrowth begins 3 to 5 months after surgery, after the shedding period.) A review of the literature--and personal discussions with surgeons whose hair transplant experience spans 25 years--revealed no evidence of a similar report. In addition, two of the remaining 10 patients had regrowth less than 4 weeks after postsurgical telogen effluvium. Neither patient age nor number of grafts transplanted played a predictive role. The location of the operative procedure also failed to predict, or preclude, successful regrowth. Topical minoxidil may be an important adjunctive therapy during the recuperative period in patients who have undergone hair transplant surgery. Carefully controlled studies are needed to substantiate this preliminary observation.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3558912&dopt=Abstract
J Nutr. 1987 Feb;117(2):376-82.
Genetic differences in effects of food restriction on aging in mice.
Harrison DE, Archer JR.
Lifelong food restriction to two-thirds of normal ad libitum consumption extended mean and maximum life spans more than 200 d in male B6CBAF1 hybrid mice, already a long-lived genotype. The following biological systems were improved by food restriction, with values for older mice being similar to those previously found for younger individuals: tight wire clinging, a measure of neuromuscular performance; open field movement, a measure of voluntary activity; tail tendon denaturation rate, a measure of collagen solubility; urine concentrating ability, a measure of renal function, and hair regrowth rate, a measure of the frequency of hair follicle cycling. However, wound healing was slower in food-restricted mice than in ad libitum-fed controls. The same food restriction treatment had entirely different effects on longevities of a different genotype, male B6 (C57BL/6J) mice, reducing mean and maximum life spans 265 and 27 d, respectively. This surprising deleterious effect was not predicted by tests of tight wire clinging, open field movement and tail tendon denaturation, but was predicted by hair regrowth rates, as these were lower in restricted B6 mice than in fed controls. In genetically obese (ob/ob) B6 mice, food restriction extended mean and maximum longevities 327 and 440 d, yet no biological systems tested performed better than those of food-restricted normal (+/+) mice whose life spans were reduced. Thus the food restriction regimen that increased longevities for individuals of two genotypes decreased them for individuals of a third genotype tested in the same set of experiments.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3559752&dopt=Abstract
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