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References: Hair growth and hair loss

Z Hautkr. 1988 Feb 15;63(2):94, 96, 99-100.
[Therapy of alopecia areata with diphenylcyclopropenone]

[Article in German]

Ochsendorf FR, Mitrou G, Milbradt R.

Zentrum der Dermatologie und Venerologie Abt. II.

With special regard to practical aspects, we discuss the treatment of alopecia areata by topical immunotherapy with diphenylcyclopropenone. Out of 27 patients treated this way, 10 patients showed good and cosmetically acceptable regrowth of terminal hair; 11 patients showed some regrowth, which was not satisfactory, however, for cosmetic reasons; 6 patients developed no hair growth at all. The complete failure of treatment in the latter cases may possibly be due to the long duration of the alopecia.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3376515&dopt=Abstract

Geburtshilfe Frauenheilkd. 1988 Apr;48(4):203-14.
[Hormonal diagnosis in so-called androgenetic alopecia in the female]

[Article in German]

Moltz L.

Androgenetic alopecia (a.A.) occurs quite frequently. Up to 79% of women suffer at least temporarily from varying degrees of intermittent diffuse hair loss in the centro-parietal and/or fronto-temporal regions. A.A. is caused by an androgen excess acting on the hair follicle for prolonged periods of time in the presence of a genetic predisposition. However, often hyperandrogenemia cannot be demonstrated in such patients. 125 women with clinically typical a.A. were investigated prospectively under standardized conditions. Patient age ranged from 18 to 68 years (mean +/- SD: 34 +/- 11.6). Atypical uterine bleeding such as menorrhagia, hypermenorrhea and polymenorrhea were found in 69 women. The hair loss varied between 50 and 400 hairs per day (124 +/- 125). Additional signs of hyperandrogenism, i.e. seborrhea (n = 83), acne (n = 52) and hirsutism (n = 28), were often observed. Basal levels of total and free testosterone (T and FT), dihydro-T (DHT) DHEA-sulfate (DS), delta 4-androstendione (A), 17 alpha-hydroxy-progesterone (17P), cortisol (F), progesterone (P), 17 beta-estradiol (E2), sex hormone binding globuline (SHBG), prolactin (PRL), thyreoidea-stimulating hormone (TSH), ferritin (Fe), vitamin B12 (B12) and folat (Fo) were determined by RIA. FT was also measured by equilibrium dialyses. Different methods of determining bound and unbound T were used; their diagnostic value is discussed in detail. In addition, a combined ACTH/TRH-stimulation test was performed in all patients. Pathologic changes of one parameter were detectable in 26.4% of patients, while 67.2% revealed deviations of two or more indices. Excluding clinically relevant borderline values, only 6.4% of patients were without any abnormalities. The incidence rate of pathologic parameters was as follows: FT in % = 52%, Fe = 42%, PRL = 34%, E2 = 34%, FT in pg = 29%, DHT = 28%, SHBG = 26%, TSH = 20.8%, DS = 19%, T = 14%, 17P = 11%, Fo = 7%, A = 6%, F = 6%, B12 = 5%. Group and individual case analyses revealed significant correlations between (1) the levels of the various androgens, PRL and TSH and (2) the E2, SHBG and FT values; these, in turn, were correlated to (3) the occurrence of certain bleeding anomalies (amount, duration, interval) and corresponding ferritin deficiency. Therapy was directed at normalizing the disturbed estrogen-androgen-balance. Using low-dose antiandrogens, estrogens, prolactin suppressants, corticoids, iron-II-preparations as well as estrogen-containing hair lotions hair loss was arrested in 74 of 104 treated women, while regrowth of hair was accomplished in 16 patients. 14 women did not respond to therapy.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3378687&dopt=Abstract

Aesthetic Plast Surg. 1987;11(4):223-7.
Electroepilation using insulated needles.

Kobayashi T, Kamiyama G.

We have practiced electroepilation using insulated needles on approximately 500 patients over a five-year period using electroepilation equipment that produced a thermolysis (high frequency) current. Our patients were given three to eight treatments at two-week to three-month intervals. The results for 73 patients, observed six months to three years after their last epilation, showed little or no hair regrowth and no scarring. We attribute our success to concomitant factors: We were able to destroy the hair papilla using a long-duration, high-frequency current while protecting the skin surface from scarring by using an insulated needle.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3445813&dopt=Abstract

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