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References: Hair growth and hair loss

Obes Surg. 1996 Feb;6(1):63-65.
Reversal of Hair Loss following Vertical Gastroplasty when Treated with Zinc Sulphate.

Neve HJ, Bhatti WA, Soulsby C, Kincey J, Taylor TV.

Research Psychologist, Department of Clinical Psychology, Gaskell House, Swinton Grove, Manchester, M13, UK.

BACKGROUND: Nutritional complications following surgery for morbid obesity include both vitamin and mineral deficiency. Severe cases of zinc deficiency can lead to alopecia, diarrhea, emotional disorders, weight loss, intercurrent infection, bullous-pustular dermatitis and hypogonadism in males. Hair loss may occur after vertical gastroplasty (VG). METHODS: Diffuse hair loss occurred in 47 out of 130 patients who underwent VG. All patients had been routinely advised to take a multivitamin supplement, but 47 developed hair loss despite taking the supplement. These patients were then prescribed Zinc Sulphate 200 mg three times a day. There was no alteration in the vitamin supplementation. RESULTS: Arrest of hair loss and regrowth occurred in all patients. However, five patients reported recurrence of hair loss after stopping zinc. This loss was reversed within 6 months of recommencing zinc 600 mg daily. Ten control patients had no hair loss after gastrointestinal surgery. CONCLUSION: Significant hair loss occurred in about one-third of patients after VG, and was reversed by zinc supplementation.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10731253&dopt=Abstract [PubMed - as supplied by publisher]

Acta Derm Venereol. 1986;66(3):269-72.
Topical immunotherapy of alopecia areata. A follow-up study.

Valsecchi R, Cainelli T, Foiadelli L, Rossi A.

Ninety-six patients suffering from alopecia areata have been treated with topical immunotherapy. Fifty-one have been treated with dinitrochlorobenzene and 45 with squaric acid dibutylester. Analysis of our group showed that 55 patients out of those 96, who entered the study, experienced hair regrowth during a period of 6-17 weeks of treatment. Of these 55 patients, 25 (45.4%) had a recurrence of AA and 30 (53.6%) had a persistent regrowth during a follow-up of 16 months-6 years. The severity and early development of flare-up and induced allergic contact dermatitis have been the principal factors that have influenced the clinical results.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2426909&dopt=Abstract

Acta Derm Venereol. 1986;66(6):485-90.
Immunohistological evaluation of alopecia areata treated with squaric acid dibutylester (SADBE).

Johansson E, Ranki A, Reunala T, Kianto U, Niemi KM.

A total of 19 patients with alopecia areata volunteered for serial biopsies of the scalp skin during SADBE treatment. Regrowth of terminal hair was seen in 12 of the 19 patients on the side of the scalp treated with SADBE for a minimum of four months, but not on a control side treated with sodium lauryl sulphate (SLS). Immunocompetent cells were characterized with ANAE staining and monoclonal antibodies in biopsy specimen showing marked peribulbar and perivascular inflammatory cell infiltrates. Inflammatory cell subclasses were repeatedly evaluated during SADBE treatment. No specific alterations in lymphocyte subclasses and macrophages were seen in relation to the hair growth response. In immunofluorescent studies it was found that in patients with regrowth of hair, immunoglobulins, fibrin and complement, appeared in the hair bulb and along the basement membrane during the treatment. Results were negative in patients without regrowth of terminal hair and in SLS-treated skin. As we could not demonstrate that any cell-mediated mechanism was involved, we suggest that SADBE may induce terminal hair growth through as yet uncharacterized mediators.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2433867&dopt=Abstract

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