References: Hair growth and hair loss
Z Hautkr. 1990 Feb;65(2):132-4, 137-8.
[Selective changes in lymphocytic differentiation antigens in the peripheral blood of patients with alopecia areata treated with oral zinc]
[Article in German]
Lutz G, Kreysel HW.
Universitats-Hautklinik und Poliklinik Rheinische Friedrich-Wilhelms-Universitat Bonn.
Recent research has shown that the regrowth of hair in alopecia areata (AA) is associated with the normalization of the CD4+/CD8+ ratio, which is usually in an unbalanced state. This dysbalance is represented by an increased level of CD4+ and a decrease of CD8+ cells and found not only in the bulbar region but also in the peripheral blood. Since zinc generally acts as a polyclonal T-cell activator and has been proved a useful oral therapeutic in AA, we additionally controlled the levels of CD4+ and CD8+ cells as well as other lymphocyte subpopulations in the peripheral blood of AA patients before and during oral treatment with zinc. Our data revealed a significant raise of CD3+, CD8+, CD19+, HLA-DQ+, HLA-DR+, and Leu 2a+8+ cells during oral therapy with zinc. We conclude that the successful treatment of AA with zinc may be due to immunomodulation, especially through the increase of CD8+ cells.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1971470&dopt=Abstract
Bone Marrow Transplant. 1991 Jan;7(1):43-7.
Busulphan/cyclophosphamide conditioning for bone marrow transplantation may lead to failure of hair regrowth.
Baker BW, Wilson CL, Davis AL, Spearing RL, Hart DN, Heaton DC, Beard ME.
Haematology Department, Christchurch Hospital, New Zealand.
Following the introduction of bulsulphan and cyclophosphamide (BUCY) conditioning in our unit in 1987, a number of patients noted incomplete scalp hair regrowth following bone marrow transplantation (BMT). Between August 1987 and May 1989, 22 patients had undergone allogeneic or autologous BMT in our unit and we recalled for detailed assessment the 14 who were alive and well at least 6 months post grafting. Six patients had experienced incomplete hair regrowth of varying severity 7-27 months following BMT. All those affected had received BUCY conditioning and the four most severely affected were allogeneic BMT recipients. No patient had received any post-BMT chemotherapy or radiation. None of the patients had evidence of graft-versus-host disease. No laboratory test abnormalities distinguished the affected from the unaffected patients. Despite the relatively small number of patients, our results suggest that BUCY has caused permanent damage to the hair follicles of the affected patients. Prolonged alopecia may markedly impair the quality of life for long-term survivors of BMT and this unexpected complication also has significant medicolegal implications.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2043877&dopt=Abstract
J Indian Med Assoc. 1991 Jan;89(1):9-10.
Dinitrochlorobenzene therapy in alopecia areata.
Kalam A, Tahseen MD, Islam SF, Rahmatullah MD, Faruqi NA.
Department of Medicine (Skin and Venereal Diseases), JN Medical College, Aligarh Muslim University.
With topical therapy using dinitrochlorobenzene (DNCB), 36 (72%) out of 50 patients having alopecia areata showed regrowth of hair in 3 to 6 months time. Five (10%) patients experienced marked vesiculation and severe contact dermatitis requiring cessation of therapy. In 7 (14%) patients there was no response at all and 4 (8%) presented with other side-effects.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2051045&dopt=Abstract
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