References: Hair growth and hair loss
J Am Acad Dermatol. 2003 Dec;49(6):1071-80.
Permanent hair removal with a diode-pumped Nd:YAG laser: a pilot study using the direct insertion method.
Hashimoto K, Kogure M, Irwin TL, Tezuka K, Osawa T, Kato K, Ebisawa T.
Department of Dermatology, Wayne State University, Detroit, Michigan, USA.
BACKGROUND: The removal of unwanted hair with various laser systems and related procedures has been investigated for many years. All researchers have met difficulty when trying to achieve "permanent" hair removal. In addition, damage to the epidermis and other complications, including hyper- or hypopigmentation in pigmented skin, have occurred because the laser energy was applied indirectly to the hair bulb through the epidermis. OBJECTIVE: To achieve permanent hair removal with the use of a diode-pumped neodymium:yttrium-aluminum-garnet laser system with an insulated optical needle. Also, to establish laser treatment parameters that allow for quick and effective removal of hair with minimal pain and no long-term medical complications. METHOD: The laser used in the study was capable of producing up to 500 mJ of energy per burst at a 1,064-nm wavelength. A pulse width of 200-500 micros and a burst frequency of 100-200 Hz could be selected, and both defined a subset of the treatment parameter space. An optical needle, typically 130 microm in diameter, was prepared before each new treatment was conducted. Three bursts of energy, 300 mJ each, with a 300-millisecond interval, were delivered through the optical needle into each hair follicle. Between 200 and 300 shin hairs, typically terminal hairs, on each of 5 volunteers were treated. These volunteers were observed over 18.5-30 months for the regrowth of hairs by hair count. RESULTS: At the end of the observation period (6-30 months after the last treatment), 3 of 5 volunteers showed permanent loss of 76%-94.3% of their unwanted hair. One volunteer lost 34.8% of the original hair, but regrown hair was much thinner than the original terminal hair. One volunteer lost only 22.8% of the original hair, and regrown hair was coarse terminal hair. Except for the loss of hair, no change in skin texture, sensation, or skin color was observed. CONCLUSION: The direct insertion optical method (DIOM), delivering laser energy directly to the hair bulb through an optical needle, has proven to be effective and achieves permanent hair removal in 60% of volunteers without medical complications.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14639387&dopt=Abstract
bouhanna.com
BACKGROUND: Medical treatment or surgical reconstruction is used separately to treat androgenetic alopecia. Two drug molecules (5% minoxidil solution and oral finasteride 1 mg) have proven efficacy to stabilize hair loss and promote hair regrowth. Microtransplant of one to three hair follicular unit grafts can provide a definitive hair restoration with a natural appearance. OBJECTIVES: Aesthetic results can be optimized with a combination of drugs and transplantation of follicular unit grafts. The Dynamic Multifactorial Classification is used to select suitable candidates for this combined approach and also to assess follow-up results. RESULTS: Dynamic Multifactorial Classification assists the evaluation of the natural history of androgenetic alopecia evolution and also the effects of treatment. Regression of male androgenetic alopecia from Hamilton type V to type III can be achieved by combining drugs with hair grafts. CONCLUSION: Improvement of investigative methods and especially the Dynamic Multifactorial Classification makes it easier for a patient to follow the results of treatment adapted to their case.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14641340&dopt=Abstract
Biol Pharm Bull. 1999 Nov;22(11):1249-50.
Studies of the active substances in herbs used for hair treatment. III. Isolation of hair-regrowth substances from Polygara senega var. latifolia TORR. et GRAY.
Ishida H, Inaoka Y, Okada M, Fukushima M, Fukazawa H, Tsuji K.
School of Pharmaceutical Science, University of Shizuoka, Japan.
Four active principles, 1, 2, 3 and 4, were isolated from Polygara senega var. latifolia TORR. et GRAY by a combination of partition and column chromatography on silica gel and octadecyl silica gel (ODS), monitored by a hair-regrowth activity assay. Compounds 1, 2, 3 and 4 were identified as senegose A, senegin II, senegin III, and senegasaponin b by comparison of their spectral data with those of authentic samples.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10598039&dopt=Abstract
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