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References: Hair growth and hair loss







BMJ. 1992 Oct 3;305(6857):799-801.
Effect of maintenance chemotherapy in childhood on numbers of melanocytic naevi.

Baird EA, McHenry PM, MacKie RM.

Department of Dermatology, University of Glasgow, Royal Hospital for Sick Children.

OBJECTIVE--(a) To determine whether children given chemotherapy for haematological malignancy have significantly more melanocytic naevi than age matched children in the local population; (b) to establish whether any observed variation in naevus counts from normal is seen at the start of maintenance chemotherapy. DESIGN--Follow up of 29 consecutive children starting maintenance chemotherapy, with parental interview and count of all melanocytic naevi > or = 2 mm on the child's skin. Assessment repeated three years later after completion of maintenance chemotherapy. Other dermatological problems identified at either visit were also recorded. SETTING--Royal Hospital for Sick Children, Glasgow. RESULTS--At the start of maintenance chemotherapy all children had total body counts of melanocytic naevi within the normal range established for age matched children in the local population. Three years later total body naevus counts were significantly increased, the median increase being 66 naevi per child (95% confidence interval 57 to 94). The only other problem noted in these children was relatively poor regrowth of scalp hair. CONCLUSION--Children on maintenance chemotherapy for haematological malignancies develop an excessive number of melanocytic naevi. Excessive numbers of melanocytic naevi are the most important risk factor for melanoma in the general population. These children should have periodic skin examinations at their follow up visits, and both child and parent should be educated about clinical features of early melanoma.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1422359&dopt=Abstract

ukonline.co.uk

Lasers have been established as effective treatment for hair removal, with possible long-term suppression of hair growth in treated areas. The purpose of this study was to assess long-term hair regrowth after treatment with the ruby laser. Volunteers recruited into the 1997-99 study were divided between three treatment groups, each having left and right treatment sides. Two treatments were given on both sides at monthly intervals. A third treatment was given randomly to one side. Hair counts of the experimental sites were made at monthly intervals for 1 year. The three patient groups were: top lip (25), axillae (25) and legs (19). Long-term hair reduction was achieved in all patients. A single treatment reduced hair counts by up to 75. Three treatments had an impact for 2 additional months, but not long term. Unexpected spontaneous hair reduction was found 5 months following treatment and lasted 2 months. This ruby laser produced a persistent two-thirds reduction in hair count over 8 months of follow-up. Extension of the follow-up to 12 months did not show significant regrowth. Existing experimental data, together with the results of this study, suggest that hair shaft damage is the key feature in achieving damage to the hair-producing mechanism. The correlation of treatment success and anagen growth phase is less likely.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14505201&dopt=Abstract [PubMed - in process]




Biol Pharm Bull. 1999 Nov;22(11):1189-92.
Studies of the active substances in herbs used for hair treatment. II. Isolation of hair regrowth substances, acetosyringone and polyporusterone A and B, from Polyporus umbellatus Fries.

Ishida H, Inaoka Y, Shibatani J, Fukushima M, Tsuji K.

School of Pharmaceutical Science, University of Shizuoka, Japan.

Fractionation of the 50% ethanol extract of Polyporus umbellatus Fries by column chromatography on Amberlite XAD-2, silica gel, Sephadex LH-20 and octadecyl silica gel (ODS) (C18)) monitored by a hair-regrowth activity assay, afforded three active principles, 1, 2 and 3. The structures of 1, 2 and 3 were determined as acetosyringone, polyporusterone A, and polyporusterone B by comparison of their spectral data with that of authentic samples, respectively. The effects of several compounds related to acetosyringone, 3,4-dihydroxybenzaldehyde or polyporusterone A on hair regrowth were also investigated.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10598026&dopt=Abstract





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