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References: Hair growth and hair loss







Birth Defects Orig Artic Ser. 1971 Jun;7(8):69-85.
The genetics of human hair growth.

Porter PS.

The regulation of human hair growth is one of the most mysterious of biologic events. Genetic factors are responsible for the density, length, color and texture of hair. Heredity disorders can affect either hair alone, hair and other ectodermal structures, or can be pansystemic. This paper considers all heredity disorders which affect human hair growth. These disorders are divided into three categories: 1) the dysmorphic syndromes; 2) the modifier gene abnormalities and 3) the single major gene abnormalities. The disorders in these categories are listed, along with the mode of inheritance, cause, hair phenotype and the extent of involvement. The utilitarian function of the study of human hair growth is illustrated. Insight into problems of differentiation can be most rapidly expanded using this approach.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=5173315&dopt=Abstract





EMBO J. 2003 May 15;22(10):2400-10.
Laminin-10 is crucial for hair morphogenesis.

Li J, Tzu J, Chen Y, Zhang YP, Nguyen NT, Gao J, Bradley M, Keene DR, Oro AE, Miner JH, Marinkovich MP.

Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, CA 94305, USA.

The role of the extracellular matrix in cutaneous morphogenesis is poorly understood. Here, we describe the essential role of laminin-10 (alpha5beta1gamma1) in hair follicle development. Laminin-10 was present in the basement membrane of elongating hair germs, when other laminins were downregulated, suggesting a role for laminin-10 in hair development. Treatment of human scalp xenografts with antibodies to laminin-10, or its receptor beta1 integrin, produced alopecia. E16.5 Lama5 -/- mouse skin, lacking laminin-10, contained fewer hair germs compared with controls, and after transplantation, Lama5 -/- skin showed a failure of hair germ elongation followed by complete hair follicle regression. Lama5 -/- skin showed defective basement membrane assembly, without measurable increases in anoikis. Instead, Lama5 -/- skin showed decreased expression of early hair markers including sonic hedgehog and Gli1, implicating laminin-10 in developmental signaling. Intriguingly, treatment of Lama5 -/- skin with purified laminin-10 corrected basement membrane defects and restored hair follicle development. We conclude that laminin-10 is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12743034&dopt=Abstract





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