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References: Hair growth and hair loss







Clin Endocrinol (Oxf). 1980 Nov;13(5):431-5.
Plasma testosterone glucosiduronate: a reliable indicator of female hyperandrogenism (idiopathic hirsutism and androgenic alopecia).

Tamm J, Volkwein U, Tresguerres JA.

Plasma concentrations of testosterone glucosiduronate (TG) have been determined by direct radioimmunoassay in seventeen normal females, twenty females with idiopathic hirsutism, and in twelve female subjects with androgenetic alopecia without hirsutism, respectively. The corresponding mean concentrations (+/- SD) of TG were 0.47 +/- 0.18; 1.42 +/- 0.55; 0.96 +/- 0.22 ng/ml. There was no overlapping of plasma TG levels of both groups with hyperandrogenism with those obtained in normal females. On the contrary, plasma concentrations of testosterone and dihydrotestosterone were found within the normal ranges in about 50% of the patients with hyperandrogenism. The synchronously estimated urinary excretion of TG revealed marked fluctuations (mean +/- SD): 27.0 +/- 12.0; 60.5 +/- 24.6; 36.3 +/- 14.1 microgram/24 h respectively.

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Br J Dermatol. 1999 Mar;140(3):432-7.
Partial restoration of hair growth in the DEBR model for Alopecia areata after in vivo depletion of CD4+ T cells.

McElwee KJ, Spiers EM, Oliver RF.

Department of Biological Sciences, University of Dundee, Dundee, DD1 4HN, U.K.

Alopecia areata (AA) is widely believed to be an autoimmune disease. Hair loss is associated with a peri- and intrafollicular inflammatory infiltrate of anagen hair follicles primarily composed of CD4 + and CD8 + cells. A previous investigation involved in vivo depletion of CD8 + cells in the DEBR rat model to examine the cells' potential pathogenic activity in AA. The rat model is used here in a comparable study of CD4 + cell pathogenic activity. Eight AA affected DEBR rats were given intraperitoneal injections of a CD4 + cell depleting OX-35/OX-38 monoclonal antibody (MoAb) cocktail over a 15-day therapy course. A further eight AA-affected rats comprised a control group and were injected with equivalent volumes of an irrelevant MoAb, OX-21. Changes in both CD4 + and CD8 + peripheral blood cell populations were analysed by flow cytometry, and macrophotography was used to record any changes in hair growth. Of the eight CD4 + cell-depleted rats six responded with hair growth. The rats revealed significant hair growth within 23 days of treatment initiation. With rapid replacement of the CD4 + cell population the newly generated pelage hair was eventually lost. Two control rats also showed limited hair growth within the 112-day study period. In vivo depletion of CD4 + cells partially restores hair growth in AA affected rats. The response suggests that CD4 + cells may be actively involved in the pathogenesis of AA. Further research may elucidate whether CD4 + cells have a direct effect on hair follicles or exert their influence through their classic T helper cell supporting role for CD8 + cells.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10233262&dopt=Abstract









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