References: Hair growth and hair loss
Acta Derm Venereol. 1975;55(6):493-6.
Large doses of glucocorticoid in the treatment of alopecia areata.
Burton JL, Shuster S.
Severe extensive alopecia areata (totalis) was treated with prednisolone as a single 2 g dose i.v. (22 patients) or 0.5 g daily for 5 days orally (13 patients). Four of the patients responded well, 12 had a poor response and 19 had no response. There was a relapse in some at about 6 months, which could be arrested by a further single i.v. dose, but the risks of this form of therapy are unclear and it cannot be recommended for general use. The clinical response to a single dose of corticosteroid implies, however, that there may be a 'switch' mechanism in certain auto-immune diseases, with an all-or-none response.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=55045&dopt=Abstract
Biosci Biotechnol Biochem. 1999 Dec;63(12):2219-21.
Activity of glucose-6-phosphate 1-dehydrogenase in hair follicles with male-pattern alopecia.
Adachi K, Watanabe Y, Inouye K.
Research and Development Headquarters, Lion Corporation, Kanagawa, Japan.
Activity of glucose-6-phosphate 1-dehydrogenase (G6PDH) in human hair follicles was measured. A good relationship has been demonstrated between the activity and the ratio of the number of the anagen hairs to that of all the plucked hairs in the frontal-parietal region of the scalp with male-pattern alopecia. As the ratio becomes lower so that the advancing degree of alopecia is higher, the G6PDH activity becomes lower.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10664855&dopt=Abstract
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