References: Hair growth and hair loss
Bratisl Lek Listy. 1995 Mar;96(3):144-7.
[Alopecia areata--an autoimmune disorder?]
[Article in Slovak]
Jautova J, Jarcuskova D, Ficova M, Dubivska M.
Kozna klinika Lekarskej fakulty Univerzity P.J. Safarika a Fakultnej nemocnice s poliklinikou v Kosiciach.
The authors indicated examinations of actual immune states in 42 patients with alopecia areata in whom no cause of the disease was stated. The examination revealed a deficit in the cellular component of immunity and an increased level of immunoglobulin M and C3 component of complement. The examination of these patients included also the direct immunofluorescence examination of a skin excision from the alopetic focus. Out of 43 examined patients 30 had positive immunocomplex findings. Immunocomplexes were most frequently constituted of M immunoglobulin, C3 component of complement, as well as of A and G immunoglobulins. Immunocomplexes were localized in the lower and sometimes in the medium part of the folicle or perifolicullary, the intensity of fluorescence depended on the severeness of the disease. The deficit in the cellular component of immunity, dysimmunoglobulinemia in the peripheral blood and a positive immunocomplex findings in hair folicles at the examination of skin excisions from the alopetic focus by means of direct immunofluorescent method enables to include the disease of alopecia areata among autoimmune disease. The conclusion deals with the possibilities of utilization of local and general immunomodulation therapy. (Tab. 2, Fig. 1, Ref. 20.)
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7633928&dopt=Abstract
Tumori. 1982 Apr 30;68(2):105-11.
Toxic and therapeutic activity of 4'-epi-doxorubicin.
Bonfante V, Villani F, Bonadonna G.
A Phase I-II study with 4'-epi-doxorubicin (epi-DX) was performed in 108 patients with various types of advanced malignancy. The pattern of acute toxicity was similar to that of doxorubicin (DX). However, epi-DX was better tolerated than DX because of comparative lower incidence of vomiting, stomatitis, complete alopecia and severe myelosuppression. Cardiac toxicity was studied by utilizing noninvasive methods, and the electrocardiographic results suggested a slightly lower cardiac damage after epi-DX compared to DX. Antitumor activity was documented in a variety of neoplasms, and objective response was also observed in those considered refractory to DX such as malignant melanoma and renal cancer. X
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6957068&dopt=Abstract
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