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References: Hair growth and hair loss







Hautarzt. 1989 Feb;40(2):77-83.
[The Brocq pseudopelade--a disease picture or disease entity]

[Article in German]

Braun-Falco O, Bergner T, Heilgemeir GP.

Dermatologische Klinik, Ludwig-Maximilians-Universitat Munchen.

In 1885 Brocq described a type of scarring alopecia he called pseudopelade (PPB), whose character as a separate disease entity has been denied in recent decades. Several authors now believe PPB to be a polyetiological final stage (etat pseudopeladique de Degos; EPP). In all, 142 patients with scarring alopecia were analyzed in an attempt to find whether PPB is a separate entity or not. Following examination, 26 cases with lichen ruber (LR), 18 cases with lupus erythematosus chronicus discoides (DLE), 2 cases with scleroderma, 1 case with folliculitis decalvans, and 1 case with ichthyosis vulgaris were diagnosed; this left 94 cases with PPB (66%). We attempt to describe the macroscopic morphology and histopathology in PPB and in LR and DLE. The findings yielded by direct immunofluorescence and the treatment are discussed.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2654076&dopt=Abstract








Arch Dermatol. 1977 May;113(5):583-7.
Mixed connective tissue disease syndrome.

Gilliam JN, Prystowsky SD.

Fifteen patients with epidermal nuclear staining on direct immunofluorescence of normal skin and high titer serum antibody to ribonuclease-sensitive extractable nuclear antigen (ENA) had diffuse nonscarring and focal alopecia, abnormal pigmentation, swollen hands with sclerodactyly, and chronic cutaneous lupus erythematosus (LE) as the most common dermatologic features. Direct immunofluorescence of normal, unexposed skin revealed a particulate ('speckled') epidermal nuclear staining pattern in all 15 patients and subepidermal immunoglobulin deposits in 5. Ribonucleoprotein antibodies in high titer are associated with this characteristic type of epidermal nuclear staining. These findings provide easily detectable markers for a less aggressive subset of LE characterized by distinctive clinical and laboratory features consistent with mixed connective tissue disease.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=67824&dopt=Abstract





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