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References: Hair growth and hair loss







J Dermatol Sci. 1990 May;1(3):183-94.
The effects of topical diazoxide on hair follicular growth and physiology of the stumptailed macaque.

Uno H, Kemnitz JW, Cappas A, Adachi K, Sakuma A, Kamoda H.

Wisconsin Regional Primate Research Center, University of Wisconsin-Madison 53715-1299.

Diazoxide, an anti-hypertensive agent, has diverse pharmacologic effects; hypertrichosis, hyperglycemia associated with suppression of insulin release, and elevation of serum levels of androgens. Taking advantage of the hypertrichotic side effects of diazoxide, we examined the effect of topical application of the drug on hair regrowth in the bald frontal scalp of stumptailed macaques (Macaca arctoides); we also monitored systemic side effects. Using 7 adult stumptails, we applied diazoxide (5% solution in a vehicle) topically on the bald frontal scalp, once a day, 5 days per week. Two of seven macaques had vehicle alone applied. Hair growth was monitored by photographic recording (once every month) and by sequential analysis of folliculograms from biopsied skin (once every 4 months). We also examined body weight, hematology, blood pressure, heart rate, serum levels of testosterone and dihydrotestosterone, and glucose tolerance for a 4-month period. All 5 diazoxide-treated animals showed thickening and maintenance of the frontal hair during the entire treatment period (16 months). Analysis of folliculograms showed progressive enlargement of hair follicular size and acceleration of its cyclic growth from telogen to anagen phase and prolongation of anagen phase in all treated animals. Controls showed no consistent progressive changes of follicular growth. None of the animals treated with diazoxide showed abnormal changes in physical growth, cardiovascular function, serum levels of androgens, glucose tolerance (including insulin levels), or hematology.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2085505&dopt=Abstract








J Periodontol. 1983 Feb;54(2):101-6.
Effect of liquid protein diet on collagen metabolism of the gingiva of young rats.

Evans GH, Yukna RA, Nakamoto T.

The effects of liquid protein diet (LPD) on gingival collagen metabolism were evaluated in young rats. Experimental animals received a LPD, while pair-fed and ad libitum groups received a 20% casein diet. Prior to sacrifice at days 23, 35 and 48 post-partum, animals from each group were injected with C14-proline. Gingival tissues from the palate were excised and analyzed for collagen content and collagen synthesis. Results of body-weight changes at day 48 showed a 20% decrease in the LPD group, while pair-fed and ad libitum groups increased 47% and 267%, respectively. Collagen content per gram of gingiva was not significantly different among the three groups. Gingival collagen synthesis, however, did show significant differences among the three groups. It was concluded that while LPD effects on the overall body condition were profound, LPD exerts minimal effect on gingival collagen metabolism in young rats.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6572715&dopt=Abstract





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