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References: Hair growth and hair loss

Arch Dermatol. 1983 Jun;119(6):501-12.
Psychosomatic concepts in dermatology. A dermatologist-psychoanalyst's viewpoint.

Koblenzer CS.

Few experienced clinicians remain unimpressed both by the influence of psychological and social factors on the physical state and by our relative inability to deal adequately with this aspect of the practice of dermatology. This article reviews the historical development of psychosomatic concepts, describes some theories concerning the process whereby somatization takes place and why a particular disease is "chosen," reviews some of the relevant basic science findings, offers a working classification of psychocutaneous disease, and, finally, makes some suggestions as to how we may become more effective in handling this important part of our clinical practice.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6859891&dopt=Abstract

Acta Derm Venereol. 1994 Jul;74(4):312-3.
Diphencyprone is not detectable in serum or urine following topical application.

Berth-Jones J, Mc Burney A, Hutchinson PE.

Department of Dermatology, Leicester Royal Infirmary, UK.

Diphencyprone is a potent contact sensitizer in widespread use for treatment of alopecia areata. It is currently not known whether this compound is absorbed following topical application. This is important, since little is known regarding potential toxicity. We therefore analysed serum and urine samples following application of at least 0.5 ml of a 1% solution of diphencyprone to the scalp of patients under treatment for alopecia areata. Serum samples were obtained over 8 h following treatment and 24-h urine collections were performed. The threshold for detection was 2 ng, and the assay gave an accurate linear response for samples of serum and urine containing known concentrations of diphencyprone. Blood and/or urine samples were obtained from a total of 18 subjects. Diphencyprone was not detected in any sample of serum or urine from the subjects. These data suggest that diphencyprone is not absorbed following application to the skin.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7976097&dopt=Abstract

Br J Radiol. 2000 Jul;73(871):745-51.
Absorbed dose and deterministic effects to patients from interventional neuroradiology.

Mooney RB, McKinstry CS, Kamel HA.

Northern Ireland Regional Medical Physics Agency, Forster Green Hospital, Belfast, UK.

Following the presentation of radiation-induced skin effects by three patients who had undergone glue embolisation of intracranial arteriovenous malformation (AVM), measurements were made of absorbed dose to the skin of patients undergoing other interventional neuroradiological procedures that involve long fluoroscopy times. The maximum absorbed dose to the skin measured by thermoluminescent dosemeters during these procedures was 4 Gy. From these measurements and from records of fluoroscopy time and the number of digital runs acquired, estimates of the maximum absorbed skin dose were made for the AVM patients. The best estimate of maximum absorbed dose to the skin received by any of the AVM patients during a procedure was 5 Gy, which is consistent with the skin effects presented by the AVM patients, that is temporary epilation and main erythema. Maximum absorbed dose to the skull was estimated to be 45 Gy and to the outer table of the skull 55 Gy. Although it is unlikely that the AVM patients will suffer serious effects from these skin doses, there remains some uncertainty over the risk of long-term effects to the skull. Examination of the fluoroscopy unit showed that the image intensifier was not performing optimally in terms of entrance dose rate and resolution. Replacement of the unit with modern X-ray equipment designed for interventional radiology was prioritized. Operators should be aware of the potential risks to patients from complex interventional neuroradiology procedures and should optimize their procedures to minimize such risks. Patients undergoing prolonged and complex procedures should be counselled regarding the symptoms and risks of large doses of radiation.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11089467&dopt=Abstract

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