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References: Hair growth and hair loss

post.tau.ac.il

OBJECTIVE: We have evaluated parameters of growth, the pubertal process and attained adult height in patients with congenital hypothyroidism (CH) of various aetiologies, diagnosed by the neonatal screening programme, and followed up longitudinally. To the best of our knowledge, no such data are available in the published literature. Our aim was to define the most important factors affecting these parameters. PATIENTS AND MEASUREMENTS: Thirty patients with CH (20 females and 10 males) diagnosed by neonatal screening (dysgenetic (n = 15), ectopic thyroid (n = 11), and enzymatic defect (n = 4)), treated with levo-thyroxine (L-T4) since the age of < or = 4 months, and followed up at intervals of 1-6 months for a mean period of 11.4 (range 5-19.6) years were evaluated. Detailed anthropometric measurements were performed by the same trained nurse, and pubertal stages were evaluated according to Tanner's criteria for breast or genitalia and pubic hair. Serum T4 and TSH levels were measured at each clinic visit using commercial kits. Bone age (BA) was determined at 6-12 months intervals using the Greulich & Pyle method. Seventeen patients attained adult height at the time of the report. RESULTS: Mean L-T4 dose of 7.9 (range 5.2-14.0) to 2.4 (range 1.3-3.4) micrograms/kg/day at various ages corrected the serum free T4(f-T4) levels to normal (> 10 pmol/l) in 95% of determinations, and the TSH level was reduced to < 10 mIU/l in 54% of the determinations during the follow-up period. Length at initiation of therapy (mean -0.15, (range -2.5-2.1) SDS), height at onset of puberty (mean -0.4, (range -1.8-1.8) SDS) and adult height (mean 0.2 (range -1.4-2.0) SDS, n = 17) were within the normal range (0.00 +/- 2 SDS). Onset and duration of puberty were normal in both sexes, and total pubertal growth contributed 19.1% (M) and 16.4% (F) to adult height. Peak height velocity (mean 10-6 (range 7.3-15.1) (M) and mean 8.0 (range 6.2-15.5) (F) cm/year) was within the normal range and occurred at the expected BA (14y; M and 12y; F). The attained average adult height was in close proximity to the average target height in both males and females. A significant positive correlation was found between the average L-T4 daily dose administered during the first 6 months of treatment and the attained adult height. CONCLUSIONS: Early detection by neonatal screening and treatment of congenital hypothyroidism enables normal prepubertal and pubertal growth and achievement of normal adult height, following normal puberty. Adult height in congenital hypothyroidism is significantly correlated with parental height and the mean L-T4 daily dose administered over the first 6 months of treatment. A dose of at least 8.5 micrograms/kg/day is recommended during this period. Periodical adjustments of L-T4 daily dose should be guided by clinical observation and serum free T4 levels.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9497870&dopt=Abstract

Acta Derm Venereol. 1998 Jan;78(1):48-51.
Evaluation of the free-running ruby laser for hair removal. A retrospective study.

Bjerring P, Zachariae H, Lybecker H, Clement M.

Department of Dermatology, University Hospital of Aarhus, Denmark.

The free-running ruby laser has recently been introduced for removal of unwanted hair growth. It is assumed that the mode of action of ruby laser depilation is that of selective photothermolysis of the melanin-rich structures. The present data reflects our results of ruby treatment of 133 patients attending a dermatological laser clinic for hair removal. When success of the laser treatment was defined as greater than 50% hair removal, 59.0% of patients reported successful results after 90 or more days after last treatment. With success defined as greater than 25% hair removal at 90 days, successful treatment was obtained in 75.0%. Also, the patients evaluated the overall result of their treatments. The percentage of patients who were either "very satisfied" or "satisfied" after 90 days was 64.2%. Only a few side-effects were observed. In general, pain was no clinical problem. No significant scarring was observed. A temporary hypopigmentation was experienced by approximately 10%, but only one patient still had hypopigmentation 90 days after treatment. Due to variability of hair density as well as anagen and telogen phase durations in different anatomical locations, firm conclusions regarding the long-term effect still cannot be drawn.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9498028&dopt=Abstract

J Anim Sci. 1998 Feb;76(2):506-12.
Macro- and micromineral composition of pigs from birth to 145 kilograms of body weight.

Mahan DC, Shields RG Jr.

Animal Sciences Department, The Ohio State University and The Ohio Agricultural Research and Development Center, Columbus 43210-1095, USA.

Body mineral composition was determined in 81 pigs killed at birth, weaning (28 d), and at approximately 15-kg intervals to 145 kg of BW. Total body components, including internal tissue, whole blood, and hair, were wet-ashed and analyzed for their mineral contents with the inductive coupled plasma method, except for Se, which was determined by fluorometric analysis. The results demonstrated that the body protein:ash ratio increased from birth to 20 kg BW, remained constant to 125 kg, but then declined to 145 kg BW (P < .01). The K:Na ratio increased from birth to 105 kg BW and then reached a plateau (P < .01). The Ca:P ratio decreased from birth to 20 kg then remained relatively constant to 90 kg BW, whereupon it increased (P < .01). These ratios reflected the rate of development of muscle and bone tissue and the higher soft tissue requirement for P and K during early growth. When expressed on a fat-free tissue basis, body Na was higher than K at birth, but thereafter body K increased linearly (P < .01) and Na content declined (P < .01). When Mg, Mn, Mo, and Cr were expressed on a fat-free empty body weight basis, each increased from birth but they maintained the same relative concentrations from 20 to 145 kg BW (P < .01). Body Fe increased from birth to 20 kg BW but then gradually declined to 145 kg BW (P < .01), whereas Zn increased to 145 kg BW (P < .01). Selenium increased from birth to weaning and again after 105 kg BW (P < .01). The amount of Co in the fat-free empty body increased linearly (P < .01) with increasing pig weight, and body Cu decreased to 75 kg BW and then reached a plateau (P < .01). The nonessential elements Al, Sr, and Sn increased dramatically from birth to weaning with a low rate of increase from 8.5 to 145 kg BW (P < .01), but Sn decreased after weaning (P < .01). The nonessential elements generally had a more variable concentration than the dietary essential trace minerals. There was a quantitative increase (P < .01) in all macro- and microelements from birth to 145 kg BW.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9498359&dopt=Abstract

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